DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6927 and Glra3

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_446176.3	Gene:	Glra3 / 114516	RGDID:	621229	Length:	480	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	140/535 - (26%)
Similarity:	242/535 - (45%)	Gaps:	111/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WSLIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRL---THGCRYDRLERPITYSETGQR 64
            |...:.:.|.....:.||.....|       :|.:..||:|   |.|  ||...||     ..:.
  Rat    33 WEAALLLSLVATKETNSARSRSAP-------MSPSDFLDKLMGRTSG--YDARIRP-----NFKG 83

  Fly    65 LPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFR-------NVSPKRRQPILGEEHL 122
            .||:|....:|....::....:.:::...|:.::.||||.:.       ::.|.          :
  Rat    84 PPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPS----------M 138

  Fly   123 RNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCST 187
            .:|:|.|.:|.|||:.::...:|..:.|..|..:|.|:.|.|:..||.|.::||.||.|.|.|..
  Rat   139 LDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIM 203

  Fly   188 VLESWMYNTSELVLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGA---FAGNYS 249
            .|||:.|..::|:..|:.:.|:.....|.|.:|:|:..           .|||:..   ..|.::
  Rat   204 QLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEE-----------KDLRYCTKHYNTGKFT 257

  Fly   250 SLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKT 314
            .:....||.|.:|:||:..::||:|||.:||||||:..|.||.|:.||.:|:||..|.:|....:
  Rat   258 CIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRAS 322

  Fly   315 LPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRS 379
            ||||||:|..::|...|.:|:|.:::|:|.||.:.|:          .|.:|:       .||:.
  Rat   323 LPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQ----------HKELLR-------FRRKR 370

  Fly   380 HARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESA 444
            ..::.:|:....::.:||.                          |:.|.||        |..:|
  Rat   371 KNKTEAFALEKFYRFSDTD--------------------------DEVRESR--------FSFTA 401

  Fly   445 FGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLS 509
            :|.....|:...:.....:..:  ....:||....::.:         :.|..||:.:|..|||:
  Rat   402 YGMGPCLQAKDGVVPKGPNHAV--QVMPKSADEMRKVFI---------DRAKKIDTISRACFPLA 455

  Fly   510 FLVFNLFFWTFVYCI 524
            ||:||:|:|. :|.|
  Rat   456 FLIFNIFYWV-IYKI 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	138/529 (26%)
		Neur_chan_LBD	36..259	CDD:280998	60/235 (26%)
		Neur_chan_memb	270..518	CDD:280999	67/247 (27%)
Glra3	NP_446176.3	LIC	28..467	CDD:273305	138/531 (26%)
		Neur_chan_LBD	63..269	CDD:280998	61/233 (26%)
		Neur_chan_memb	276..464	CDD:280999	67/249 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910