DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and FEN2

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_009957.1	Gene:	FEN2 / 850394	SGDID:	S000000623	Length:	512	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	107/516 - (20%)
Similarity:	183/516 - (35%)	Gaps:	133/516 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DSKGVSNRNRSDQEVRMERYASDGQIPRCRKTRFFVVLMLFS--------------GMANAYVMR 59
            :||.:     :..||..|..:|...|.: |...|.:.|.:.|              |..|||:
Yeast     4 ESKSI-----TQHEVERESVSSKRAIKK-RLLLFKIDLFVLSFVCLQYWINYVDRVGFTNAYI-- 60

  Fly    60 TNMSVAIVAMVNHTAISHTKSSTQSKERDGDFEWSYKLQGYILSSFFYGYVITQIPFGLMIKYYG 124
            :.|...:..:.|...:|:|                         .|..||::..:|..||:....
Yeast    61 SGMKEDLKMVGNDLTVSNT-------------------------VFMIGYIVGMVPNNLMLLCVP 100

  Fly   125 ARHFL-----GWGMMINSLAAFFIPISARSGGVVGLCVVRFIQGLGEGPIVPCSHSLLAQWVPPN 184
            .|.:|     .||::  :|..:.:.      ....:|.:||.|.|.|......:|.:|..|...:
Yeast   101 PRIWLSFCTFAWGLL--TLGMYKVT------SFKHICAIRFFQALFESCTFSGTHFVLGSWYKED 157

  Fly   185 ERSLAGAAVYAGAQFGTIVSMPLSG-----LLAHY-GFDG--GWPSIFY----------IFGLFS 231
            |..:. :|::.|:  |.:.|| .||     :..|. |.:|  ||..:|.          |:|.
Yeast   158 ELPIR-SAIFTGS--GLVGSM-FSGFMQTSIFTHLNGRNGLAGWRWLFIIDFCITLPIAIYGF-- 216

  Fly   232 TIWCIIFICLVQESPAVS----TR-ISEAERRHIMEAIWQAQPEERSRIPFLGIAKSPP-----F 286
                |.|..|..::.|||    || |...:..|.......|: :|.:|:.:..|.:...     .
Yeast   217 ----IFFPGLPDQTSAVSKFSMTRYIFNEQELHYARRRLPAR-DESTRLDWSTIPRVLKRWHWWM 276

  Fly   287 YAILVAHAGHNYGY---ETLMTMLPTYMYRVLNVNIRTNGI--------------ISSLPYLAMW 334
            ::::....|.|.|:   .|....|....|.:...|...:||              :|.:|....|
Yeast   277 FSLVWVLGGENLGFASNSTFALWLQNQKYTLAQRNNYPSGIFAVGIVSTLCSAVYMSKIPRARHW 341

  Fly   335 ----ILAIVFGILADCLIRR---NFSITVVRKLMNSLGQYGPAVALISVGFVHHSLWLTSVIFIL 392
                .:::|..|:| .|||.   |..:....:.:..:...|.||.......:.|:......|.:.
Yeast   342 HVSVFISLVMVIVA-VLIRADPLNPKVVFSAQYLGGVAYAGQAVFFSWANIICHADLQERAIVLA 405

  Fly   393 GMGL-NGAIYCGFKINHL--DLSPRFAGLLISVTNCVANLVGLMAPMVAGHVIDPKPSVEN 450
            .|.: :||:...:.|...  |:.|:|.      ..|.|.|...::..:...||......||
Yeast   406 SMNMFSGAVNAWWSILFFASDMVPKFE------RGCYALLATAISSGIVSVVIRSLQIKEN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	100/487 (21%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	98/480 (20%)
FEN2	NP_009957.1	MFS_FEN2_like	32..450	CDD:340885	94/470 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000