DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and slc17a5

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001070195.1	Gene:	slc17a5 / 767760	ZFINID:	ZDB-GENE-060929-1158	Length:	488	Species:	Danio rerio

Alignment Length:	485	Identity:	180/485 - (37%)
Similarity:	271/485 - (55%)	Gaps:	35/485 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 MERYASDGQ-------------------IPRCRKTRFFVVLMLFSGMANAYVMRTNMSVAIVAMV 70
            ||..|||.:                   .|.|..:|:.:..:...|...||.:|.|:|||:|.|:
Zfish     1 MELSASDSESEDHAQPLLRRKDTEDIQKAPACGSSRYGLAFLSCYGFFVAYALRVNLSVAMVDML 65

  Fly    71 NHTAISHTKSS---------TQSKERDGDFEWSYKLQGYILSSFFYGYVITQIPFGLMIKYYGAR 126
            .:::.::|.||         .:.......::|:.:.||:||.||||||:|||||.|.:.:.|||:
Zfish    66 KNSSKANTSSSICPPHNIPVPKHNHTAMVYDWNSETQGWILGSFFYGYIITQIPGGYLARKYGAK 130

  Fly   127 HFLGWGMMINSLAAFFIPISARSGGVVGLCVVRFIQGLGEGPIVPCSHSLLAQWVPPNERSLAGA 191
            ..||.|::...:.....|::|..|... |..||.::|:|||...|..|::.|.|.||.|||....
Zfish   131 WLLGLGILCTVIFTLLTPLAADLGAGY-LIAVRVLEGIGEGVTYPAMHAMWASWAPPLERSRLLT 194

  Fly   192 AVYAGAQFGTIVSMPLSGLLAHYGFDGGWPSIFYIFGLFSTIWCIIFICLVQESPAVSTRISEAE 256
            ..|.|||.||:|::||||.:..| .|  |..:|||||....:|..::||.|..||:...||:|||
Zfish   195 ISYTGAQLGTVVALPLSGQICFY-LD--WTYVFYIFGAVGLLWFFLWICFVSNSPSSHKRITEAE 256

  Fly   257 RRHIMEAIWQAQPEERSRIPFLGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYMYRVLNVNIRT 321
            :.:||.::.......:..||:..|.||.|.:||:|||..:|:.:.||:|:|||||..||..:|:.
Zfish   257 KTYIMSSLKNELSPTQDYIPWTSIFKSMPLWAIVVAHFSYNWTFYTLLTLLPTYMNDVLGFSIQQ 321

  Fly   322 NGIISSLPYLAMWILAIVFGILADCLIRR-NFSITVVRKLMNSLGQYGPAVALISVGFVHHSLWL 385
            ||::|:||||..|:||::.|.|||.|..| .|...:|||....:|..||||.|::.|:...:..|
Zfish   322 NGMLSALPYLGCWLLALLGGQLADLLRERFLFRTVIVRKAFTVVGMAGPAVFLVAAGYTGCNYIL 386

  Fly   386 TSVIFILGMGLNGAIYCGFKINHLDLSPRFAGLLISVTNCVANLVGLMAPMVAGHVIDPKPSVEN 450
            ......:...|.|....||.|||||::|.:||:|:.:||..|.:.|::.|::| ..:....::..
Zfish   387 AVAFLTISSSLGGISASGFNINHLDIAPSYAGILLGITNSFATIPGMVGPVIA-RSLTKSNTIPE 450

  Fly   451 WRIVFYIAAGVFIFTASFYNVFASGK-QQW 479
            |:|||||:|.:.||.|.|:.:|..|. |.|
Zfish   451 WQIVFYISAAINIFGAVFFTIFGKGTVQPW 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	171/450 (38%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	168/437 (38%)
slc17a5	NP_001070195.1	2A0114euk	27..488	CDD:129972	175/459 (38%)
slc17a5	NP_001070195.1	MFS	92..472	CDD:119392	155/384 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378598at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750