DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6978 and CG18788

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_652665.3	Gene:	CG18788 / 59164	FlyBaseID:	FBgn0042126	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	117/530 - (22%)
Similarity:	208/530 - (39%)	Gaps:	124/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KTRFFVVLMLFSGMANAYVMR-------------------------------TNMSVAIVAMVNH 72
            :.|:.:....|..:.|||.||                               .|..:.:...:||
  Fly    19 RQRWVLCCFTFLAIINAYTMRLCLDCTLNRIILECGGHRVDNVPQVLNPKALPNWRIELAMALNH 83

  Fly    73 TAI---SHTKS-------------STQSKERDGD---------------FEWSYKLQGYILSSFF 106
            |..   |..|:             .|:.:|..|:               .:|..:.|..::.:|:
  Fly    84 TEYQLRSRLKAGKEQPDLNQISAKGTRDREPAGEKRPGQEDSQERLSCSEQWPRQTQSLVVMAFY 148

  Fly   107 YGYVITQIPFGLMIKYYGARHFLGWGMMINSLAAFFIPISARSGGVVGLCVVRFIQGLGEGPIVP 171
            .|||::.:|.|.:.:.||.:..|...::.:::.....|.:.|.||:..|..||.:.|:.|||..|
  Fly   149 AGYVLSHVPGGRLAERYGGKWVLSAAILTSAVLTLLTPTAVRQGGLYALVAVRLLVGICEGPCFP 213

  Fly   172 CSHSLLAQWVPPNERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGFDGGWPSIFYIFGLFSTIWCI 236
            ...:|||||||..||.:..:.|.:|.:.|..:...:||||.   .:..||..||:.|..:..|.:
  Fly   214 AVCALLAQWVPEQERGMLASCVLSGGEIGITMVQLVSGLLI---AEQDWPVFFYLVGGGAVAWFL 275

  Fly   237 IFICLVQESPAVSTRISEAERRHIM--------------------EAIWQAQPEERSR------- 274
            .|..:...:|.....|...||.:|.                    |..::.:..|..|
  Fly   276 GFTLVCYSTPDHCPFIQSEEREYIRCNTSNSFLLTTGREREEMDGEDGYEGEDREHRREVEATCN 340

  Fly   275 -IPFLGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYMYRVLNVNIRTNG--------IISSL-P 329
             .|:..:..|.|.:|::.......:     ...||..:...|. .:|..|        ||.:: |
  Fly   341 TAPWRSMLNSTPLWALVSTSMQQEF-----QQKLPQELQIALE-EVRARGTSFSELTTIIETIAP 399

  Fly   330 YLAMWILAIVFGILADCLIRRN-FSITVVRKLMNSLGQYGPAVALISVGFVHHSLWLTSVIFILG 393
            .:..||.::..|.|:|.||.:. .:.|..|:||:.|.....::.::.:......:|     .:||
  Fly   400 SVGNWIASLTTGRLSDVLIEQQILTRTQTRRLMSWLVFLCGSMYMLQIKMSGARIW-----SVLG 459

  Fly   394 MGLNGAIYCGFKINHLDLSPRFAGLLISVTNCVANLVGLMAPMVAGHVIDPKPSVENWRIVFYIA 458
            |   ||.|...|:..||:||.:||.|:.::..:..|..|:.|.:.....|       :::|..:.
  Fly   460 M---GAYYASIKLLPLDMSPNYAGTLMGISGGMGALPALLMPYLEQLETD-------YKLVSSVR 514

  Fly   459 AGVFIFTASF 468
            |.:::..||:
  Fly   515 AAMWVIGASY 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	117/530 (22%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	116/524 (22%)
CG18788	NP_652665.3	MFS	129..>280	CDD:119392	46/153 (30%)
CG18788	NP_652665.3	MFS_1	135..498	CDD:284993	95/379 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I2672
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1933
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	8	7.970