DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and slc17a8

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001076304.1	Gene:	slc17a8 / 563467	ZFINID:	ZDB-GENE-060503-416	Length:	590	Species:	Danio rerio

Alignment Length:	447	Identity:	162/447 - (36%)
Similarity:	241/447 - (53%)	Gaps:	19/447 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RFFVVLMLFSGMANAYVMRTNMSVAIVAMVNHTAISHTKSSTQSKERDGDFEWSYKLQGYILSSF 105
            |:.:.::...|...::.:|.|:.||||.|||:..:....::..   :...|.|..:..|.|..||
Zfish    75 RYIIAMLSGLGFCISFGIRCNLGVAIVEMVNNNTVYINGTAVM---QPAQFNWDPETVGLIHGSF 136

  Fly   106 FYGYVITQIPFGLMIKYYGARHFLGWGMMINSLAAFFIPISARSGGVVGLCV--VRFIQGLGEGP 168
            |:||::||||.|.:.....|....|..:.:.|:...|||.:||   |...||  ||.:|||.||.
Zfish   137 FWGYIVTQIPGGFISNKLAANRVFGAAIFLTSVLNMFIPSAAR---VHYGCVMFVRILQGLVEGV 198

  Fly   169 IVPCSHSLLAQWVPPNERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGFDGGWPSIFYIFGLFSTI 233
            ..|..|.:.::|.||.|||......:.|:..|.:::|||:|:|..|   .||||:|||:|:|..|
Zfish   199 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQY---VGWPSVFYIYGVFGII 260

  Fly   234 WCIIFICLVQESPAVSTRISEAERRHIMEAIWQA----QPEERSRIPFLGIAKSPPFYAILVAHA 294
            |.|.:|.|...||||...|||.||.:|..:|.:.    ...|:.:.|:.....|.|.|||:||:.
Zfish   261 WYIFWILLAYNSPAVHPTISEEERNYIETSIGEGANLMSSTEKFKTPWREFFTSMPVYAIIVANF 325

  Fly   295 GHNYGYETLMTMLPTYMYRVLNVNIRTNGIISSLPYLAMWILAIVFGILADCL-IRRNFSITVVR 358
            ..::.:..|:...|.|...|....|...||:|::|::.|.|:..:.|.|||.| .|:..|.|.||
Zfish   326 CRSWTFYLLLISQPAYFEEVFGFPISKVGILSAVPHMVMTIIVPIGGQLADFLRSRKILSTTTVR 390

  Fly   359 KLMNSLGQYGPAVALISVGFVHHSLWLTSVIFILGMGLNGAIYCGFKINHLDLSPRFAGLLISVT 423
            |:||..|....|..|:.|||.|......|.: ||.:|.:|....||.:||||::||:|.:|:.::
Zfish   391 KIMNCGGFGMEATLLLVVGFSHTRAVAISFL-ILAVGFSGFAISGFNVNHLDIAPRYASILMGIS 454

  Fly   424 NCVANLVGLMAPMVAGHVIDPKPSVENWRIVFYIAAGVFIFTASFYNVFASG-KQQW 479
            |.|..|.|::.|::.|.:...|..:| |:.||.||:.|......||.:|||| ||.|
Zfish   455 NGVGTLSGMVCPLIVGALTKHKTRLE-WQHVFVIASMVHYTGVIFYAIFASGEKQDW 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	160/444 (36%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	154/434 (35%)
slc17a8	NP_001076304.1	2A0114euk	75..514	CDD:129972	162/447 (36%)
		MFS	81..503	CDD:119392	154/432 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582536
Domainoid	1	1.000	42	1.000	Domainoid score	I12425
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.650