DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and MFS18

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_608835.1	Gene:	MFS18 / 33650	FlyBaseID:	FBgn0025684	Length:	439	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	117/469 - (24%)
Similarity:	203/469 - (43%)	Gaps:	83/469 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RCRKTRFFVVLMLFSGMANAYVMRTNMSVAIVAMVNHTAISHTKSSTQSKERDGDFEWSYKLQGY 100
            |..|..:|:.|:  :|....|..||.|.:.:.|:          :|.|        :||....|.
  Fly    23 RHEKRVWFITLI--TGTCMLYSTRTTMPLLVPAV----------ASAQ--------KWSKTDSGT 67

  Fly   101 ILSSFFYGYVITQIPFGLMIKYYGARHF-----LGWGMMINSLAAFFIPI------SARSGGVVG 154
            :|||||:||.:||:..|.....:|.:..     :||     ||..|.:|.      |.:|..:..
  Fly    68 VLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGW-----SLITFLMPTIIWTAGSIKSYAIPF 127

  Fly   155 LCVVRFIQGLGEGPIVPCSHSLLAQWVPPNERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGFD-G 218
            :..:|.:.|..:|...|...||.:|.:.|||||.....:.||:..||:    |:|::..:..| .
  Fly   128 IVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTL----LTGIMGSFLLDYF 188

  Fly   219 GWPSIFYIFGLFSTIWCIIFICLVQESPAVSTRISEAERRHIMEAIWQAQ------PEERSRIPF 277
            ||..:|.:.||....|.::          :.......||..|:.....::      |.|.|.:|:
  Fly   189 GWSYVFRVIGLMGIAWALV----------LRYYAMAGERNRIINIATPSRLCANKSPAETSAVPW 243

  Fly   278 LGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYMYRVLNVNIRTNG-------IISSLPYLAMWI 335
            |...:...|:|.::.||.....:..|::.||||.:         :|       :::.:|:||:..
  Fly   244 LRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFH---------DGFPHAKGWVVNMIPWLALPP 299

  Fly   336 LAIVFGILADCLIRRNFSITVVRKLMNS--LGQYGPAVALISVGFVHHSLWLTSVIFILGMGL-N 397
            ..:....|...|:.|.:..|.|||::.|  ......|:.::|.....|:..:...|.|.|.|. |
  Fly   300 CTLFAKYLTTRLLAREWHTTTVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHN 364

  Fly   398 GAIYCGFKINHLDLSPRFAGLLISVTNCVANLVGLMAPMVAGHVIDPKPSVENWRIVFYIAAGVF 462
            .|:    .:|..||:|..:|.:..:.|.|..:.|.:...:|||:::   ..::|.:||..|||:.
  Fly   365 NAV----TVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILE---LTQSWPMVFSAAAGIN 422

  Fly   463 IFTASFYNVFASGK 476
            :.....:.||.|.:
  Fly   423 LVGWIIFIVFGSAE 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	116/467 (25%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	112/455 (25%)
MFS18	NP_608835.1	MFS	30..432	CDD:119392	112/456 (25%)
MFS18	NP_608835.1	MFS_1	32..397	CDD:284993	102/416 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452020
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.890