DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	168/495 - (33%)
Similarity:	250/495 - (50%)	Gaps:	32/495 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VYDSKGVSNR-----NRSDQEVRMERYASDGQIPRCR-----------KTRFFVVLMLFSGMANA 55
            |.||.|:..|     |.....:.:.......|..|.|           ..|:.:.:|...|...:
  Rat    25 VGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPVCDCSCCGIPKRYIIAVMSGLGFCIS 89

  Fly    56 YVMRTNMSVAIVAMVNH-TAISHTKSSTQSKERDGDFEWSYKLQGYILSSFFYGYVITQIPFGLM 119
            :.:|.|:.||||.|||: |.....|...|:.:    |.|..:..|.|..|||:||::||||.|.:
  Rat    90 FGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQ----FNWDPETVGLIHGSFFWGYIVTQIPGGFI 150

  Fly   120 IKYYGARHFLGWGMMINSLAAFFIPISARSGGVVGLCVVRFIQGLGEGPIVPCSHSLLAQWVPPN 184
            ...:.|....|..:.:.|....|||.:||......:| ||.:|||.||...|..|.:.::|.||.
  Rat   151 SNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMC-VRILQGLVEGVTYPACHGMWSKWAPPL 214

  Fly   185 ERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGFDGGWPSIFYIFGLFSTIWCIIFICLVQESPAVS 249
            |||......:.|:..|.:|:|||:|:|..|   .||.|:|||:|:|..||.:.::....|.|||.
  Rat   215 ERSRLATTSFCGSYAGAVVAMPLAGVLVQY---IGWASVFYIYGMFGIIWYMFWLLQAYECPAVH 276

  Fly   250 TRISEAERRHIMEAIWQ-AQPEERSRI--PFLGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYM 311
            ..||..||.:|..:|.: |.....|:.  |:.....|.|.|||:||:...::.:..|:...|.|.
  Rat   277 PTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYF 341

  Fly   312 YRVLNVNIRTNGIISSLPYLAMWILAIVFGILADCL-IRRNFSITVVRKLMNSLGQYGPAVALIS 375
            ..|....|...|::|::|::.|.|:..:.|.|||.| .|:..:.|.|||:||..|....|..|:.
  Rat   342 EEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLV 406

  Fly   376 VGFVHHSLWLTSVIFILGMGLNGAIYCGFKINHLDLSPRFAGLLISVTNCVANLVGLMAPMVAGH 440
            ||| .|:..:.....:|.:|.:|....||.:||||::||:|.:|:.::|.|..|.|::.|::.|.
  Rat   407 VGF-SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA 470

  Fly   441 VIDPKPSVENWRIVFYIAAGVFIFTASFYNVFASG-KQQW 479
            :...| :.|.|:.||.|||.|......||.||||| ||.|
  Rat   471 MTKHK-TREEWQNVFLIAALVHYSGVIFYGVFASGEKQDW 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	158/456 (35%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	151/432 (35%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	151/432 (35%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650