DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	432	Identity:	162/432 - (37%)
Similarity:	251/432 - (58%)	Gaps:	22/432 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PRCRKTRFFVVLMLFSGMANAYVMRTNMSVAIVAMV-NHTAISHTKSSTQSKERDG--------- 89
            |.|...|:.:.::.|.|....|.:|.|:|||:|.|| ::|.:...::|....|...
Human    33 PVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQT 97

  Fly    90 --DFEWSYKLQGYILSSFFYGYVITQIPFGLMIKYYGARHFLGWGMMINSLAAFFIPISARSGGV 152
              .::|..:.||:||.||||||:|||||.|.:....|.:..||:|::..::...|.||:|..|
Human    98 GKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLG-- 160

  Fly   153 VG-LCVVRFIQGLGEGPIVPCSHSLLAQWVPPNERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGF 216
            || |.|:|.::|||||...|..|::.:.|.||.|||...:..|||||.||::|:||||::.:|
Human   161 VGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYY-- 223

  Fly   217 DGGWPSIFYIFGLFSTIWCIIFICLVQESPAVSTRISEAERRHIMEAIWQAQPEERSRIPFLGIA 281
             ..|..:||.||.....|.:::|.||.::|....|||..|:.:|:.:: :.|...:..:|::.|.
Human   224 -MNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSL-RNQLSSQKSVPWVPIL 286

  Fly   282 KSPPFYAILVAHAGHNYGYETLMTMLPTYMYRVLNVNIRTNGIISSLPYLAMWILAIVFGILADC 346
            ||.|.:||:|||..:|:.:.||:|:|||||..:|..|::.||.:||||||..|:..|:.|..||.
Human   287 KSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADN 351

  Fly   347 L-IRRNFSITVVRKLMNSLGQYGPAVALISVGFVHHSLWLTSVIFILGMGLNGAIYCGFKINHLD 410
            | .:.|||...||::.:.:|..||||.|::.||:.....|......:...|.|....||.|||||
Human   352 LRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLD 416

  Fly   411 LSPRFAGLLISVTNCVANLVGLMAPMVAGHVIDPKPSVENWR 452
            ::|.:||:|:.:||..|.:.|::.|::| ..:.|...|: ||
Human   417 IAPSYAGILLGITNTFATIPGMVGPVIA-KSLTPDAGVQ-WR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	160/429 (37%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	159/422 (38%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	159/423 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378598at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750