DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	495	Identity:	165/495 - (33%)
Similarity:	253/495 - (51%)	Gaps:	32/495 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VYDSKGVSNR---NRSDQEVRMERYASDGQIPRCRKT-------------RFFVVLMLFSGMANA 55
            |.||.|:..|   ..:::|..:|.......:...|.:             |:.:.:|...|...:
Human    25 VGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCIS 89

  Fly    56 YVMRTNMSVAIVAMVNH-TAISHTKSSTQSKERDGDFEWSYKLQGYILSSFFYGYVITQIPFGLM 119
            :.:|.|:.||||.|||: |.....|...|:.:    |.|..:..|.|..|||:||::||||.|.:
Human    90 FGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQ----FNWDPETVGLIHGSFFWGYIMTQIPGGFI 150

  Fly   120 IKYYGARHFLGWGMMINSLAAFFIPISARSGGVVGLCVVRFIQGLGEGPIVPCSHSLLAQWVPPN 184
            ...:.|....|..:.:.|....|||.:||......:| ||.:|||.||...|..|.:.::|.||.
Human   151 SNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMC-VRILQGLVEGVTYPACHGMWSKWAPPL 214

  Fly   185 ERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGFDGGWPSIFYIFGLFSTIWCIIFICLVQESPAVS 249
            |||......:.|:..|.:|:|||:|:|..|   .||.|:|||:|:|..||.:.::....|.||..
Human   215 ERSRLATTSFCGSYAGAVVAMPLAGVLVQY---IGWSSVFYIYGMFGIIWYMFWLLQAYECPAAH 276

  Fly   250 TRISEAERRHIMEAIWQ-AQPEERSRI--PFLGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYM 311
            ..||..|:.:|..:|.: |.....|:.  |:.....|.|.|||:||:...::.:..|:...|.|.
Human   277 PTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYF 341

  Fly   312 YRVLNVNIRTNGIISSLPYLAMWILAIVFGILADCL-IRRNFSITVVRKLMNSLGQYGPAVALIS 375
            ..|....|...|::|::|::.|.|:..:.|.|||.| .|:..:.|.|||:||..|....|..|:.
Human   342 EEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLV 406

  Fly   376 VGFVHHSLWLTSVIFILGMGLNGAIYCGFKINHLDLSPRFAGLLISVTNCVANLVGLMAPMVAGH 440
            ||| .|:..:.....:|.:|.:|....||.:||||::||:|.:|:.::|.|..|.|::.|::.|.
Human   407 VGF-SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA 470

  Fly   441 VIDPKPSVENWRIVFYIAAGVFIFTASFYNVFASG-KQQW 479
            :...| :.|.|:.||.|||.|......||.||||| ||:|
Human   471 MTRHK-TREEWQNVFLIAALVHYSGVIFYGVFASGEKQEW 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	156/458 (34%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	149/432 (34%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61		3/20 (15%)
		2A0114euk	75..513	CDD:129972	157/445 (35%)
		MFS	80..502	CDD:119392	149/431 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650