DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and F41C3.2

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_494849.2	Gene:	F41C3.2 / 173821	WormBaseID:	WBGene00018268	Length:	499	Species:	Caenorhabditis elegans

Alignment Length:	507	Identity:	120/507 - (23%)
Similarity:	209/507 - (41%)	Gaps:	77/507 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SKGVSNRNR---SDQEVRMERYASDGQIPRCRKTRFFVVLMLFSGM----ANAYVMRTNMSVAIV 67
            ||.:|..:.   ||:|. :|  |...:||  .:.|:::..::...|    ||.:|.  |.:|..:
Worm     5 SKSISVEDLHQFSDEEY-VE--AKQKKIP--GRMRWYICAIVTGLMTLVQANVHVY--NFTVLCM 62

  Fly    68 ----AMVNHTAISHTKSSTQSKERDGDFEWSYKLQGYILSSFFYGYVITQIPFGLMIKYY----- 123
                ...|:.::|..::...|..   :|.:| |.:..:|.|..|   |..:| .::|.|:
Worm    63 QEEQEKANNESLSRNETILPSSL---NFNFS-KFEQDLLFSAAY---IAPLP-SIIILYFLTNRS 119

  Fly   124 GARHFLGWGMMINSLAAFFIPISARSGGVVGLCVVRFIQGLGEG------PIVPCSHSLLAQWVP 182
            |.:.......|::.|:....|| |...|.......||.|||...      .:|.|      .|..
Worm   120 GVKTTFLICSMLSFLSTILTPI-ATQYGFWFFWAARFFQGLPTAILGIVVSVVTC------HWST 177

  Fly   183 PNERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGFDGGWPSIFYIFGLFSTIWCIIFICLVQESPA 247
            ..|.....:.:.|..|...:::||||.|:...   |||.|::|..|..:.|..::|.....:.|:
Worm   178 LTENGTYVSILAAHYQIAPLLTMPLSALMCSV---GGWSSVYYTQGTITAILIVLFAVFYTDKPS 239

  Fly   248 VSTRISEAERRHIMEA-IWQAQPEERSRIPFLGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYM 311
            .|..:|:.|.:.|.:. ..:.:..|:|:.||:.|.|.|..:||.:...|...|:...:...|||:
Worm   240 ESKFVSKGELKAIEDGKSLEEKHVEKSKTPFVAIHKDPAVWAIWITSVGGTIGFSIFLQYGPTYL 304

  Fly   312 YRVLNVNIRTNGIISSLPYLAMWILAIVFGIL-ADCLIRRNFSITVVRKLMNSLGQYGPAVALIS 375
            .:||:.|:.|.|..:::||:...|..||...| |:|.........:|   ..::.|...|:..:.
Worm   305 NKVLHYNLSTTGWTAAVPYIFSCIARIVAQPLSANCSFLGERLAAIV---TTTISQGTMAICFLV 366

  Fly   376 VGFVHHSLW-----LTSVIFILGMGLNGA-------IYCGFKINHLDLSPRFAGLLISVTNCVAN 428
            :.|:..: |     |...:.|:..||||.       :.|...::.:..:..|..          .
Worm   367 LMFIPQT-WSSVGQLCYSLVIVANGLNGVGITRSAQLVCKQHMSFVYTARAFYN----------G 420

  Fly   429 LVGLMAPMVAGHVIDPKPSVENW-RIVFYIAAGVFIFTASFYNVFASGKQQW 479
            .|||..|::...|. |..:...| |:...|...||:....|....::...||
Worm   421 SVGLFLPLLVNFVA-PNDTHNEWTRLFLIIFCIVFVSNLIFIAFSSTEPAQW 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	108/473 (23%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	107/461 (23%)
F41C3.2	NP_494849.2	2A0114euk	30..471	CDD:129972	109/477 (23%)
F41C3.2	NP_494849.2	MFS	86..463	CDD:119392	98/406 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810