DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6978 and SLC17A4

DIOPT Version :9

Sequence 1:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_005486.1	Gene:	SLC17A4 / 10050	HGNCID:	10932	Length:	497	Species:	Homo sapiens

Alignment Length:	495	Identity:	154/495 - (31%)
Similarity:	251/495 - (50%)	Gaps:	35/495 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TAGVYDSKGVSNRNRSDQEVRMERYASDGQIPRCRKTRFFVVLMLFSGMANAYVMRTNMSVAIVA 68
            |.|...|.|  |.|.:.:|...:.:.|         .|..:.|:|.....:.|..:.|:|:||.|
Human    10 TVGDISSDG--NLNVAQEECSRKGFCS---------VRHGLALILQLCNFSIYTQQMNLSIAIPA 63

  Fly    69 MVNHTA-ISHTKSSTQSKERDGD----------------FEWSYKLQGYILSSFFYGYVITQIPF 116
            |||:|| .|...:||:....|..                ::||.::||.||||..||..:..||.
Human    64 MVNNTAPPSQPNASTERPSTDSQGYWNETLKEFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPS 128

  Fly   117 GLMIKYYGARHFLGWGMMINSLAAFFIPISARSGGVVGLCVVRFIQGLGEGPIVPCSHSLLAQWV 181
            |.:...:||::.:|.|:.|:|....|||::| :.||..|.|:|.:||:.:..::...:|:..:|.
Human   129 GYVAGIFGAKYVVGAGLFISSFLTLFIPLAA-NAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWA 192

  Fly   182 PPNERSLAGAAVYAGAQFGTIVSMPLSGLLAHYGFDGGWPSIFYIFGLFSTIWCIIFICLVQESP 246
            ||.|||.......:|:..|:.:.:...|||..   ..|||.:|||||......|.::..|:.:.|
Human   193 PPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQ---TIGWPYVFYIFGGIGCACCPLWFPLIYDDP 254

  Fly   247 AVSTRISEAERRHIMEAIWQAQPEERSRIPFLGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYM 311
            .....||..|:|:|:.::.|........:|...:.||.|.:||||::....:.:.|:|...|||:
Human   255 VNHPFISAGEKRYIVCSLAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYI 319

  Fly   312 YRVLNVNIRTNGIISSLPYLAMWILAIVFGILADCLI-RRNFSITVVRKLMNSLGQYGPAVALIS 375
            ..||..|:|.:||:|:||::...|..|:.|:|||.|: |:...:..:|||..::|...|:|.|:|
Human   320 SSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVS 384

  Fly   376 VGFVHHSLWLTSVIFILGMGLNGAIYCGFKINHLDLSPRFAGLLISVTNCVANLVGLMAPMVAGH 440
            :.:|..|..:|....:|...::.....|..:|.||::||:.|.|..:....|::.|.::|..||.
Human   385 LPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGF 449

  Fly   441 VIDPKPSVENWRIVFYIAAGVFIFTASFYNVFA-SGKQQW 479
            .|. :.|...||.||.::|.|.|....||.:|. :..|.|
Human   450 FIS-QDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDW 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	144/458 (31%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	142/445 (32%)
SLC17A4	NP_005486.1	UhpC	30..491	CDD:332119	147/473 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148637
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740