DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and MSN2

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_013751.1	Gene:	MSN2 / 855053	SGDID:	S000004640	Length:	704	Species:	Saccharomyces cerevisiae

Alignment Length:	294	Identity:	67/294 - (22%)
Similarity:	109/294 - (37%)	Gaps:	101/294 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SNNNTNTN----------GNIQVGLPHVEDPSLFIDF---------NDLTVCPPDLSDWEQRLLD 113
            |:||::||          ...:..||.::| ||..|.         ||: :...:||..:|.:..
Yeast   428 SHNNSSTNMKSFNSDLYSRRQRASLPIIDD-SLSYDLVNKQDEDPKNDM-LPNSNLSSSQQFIKP 490

  Fly   114 NYVEIPDLVDFLPERTPLCTDNCADFL-EESNSNLRLSGPPHSEIFVPDRSSS--SPGSSDSAS- 174
            :.: :.|....:.:.......|...|| ||...|  .:..|:.::.:...:.:  ||.||.|.|
Yeast   491 SMI-LSDNASVIAKVATTGLSNDMPFLTEEGEQN--ANSTPNFDLSITQMNMAPLSPASSSSTSL 552

  Fly   175 --------------------------------PAEAVAP---------PSALQMSENAAG---ER 195
                                            |.....|         .|::..:.|.||   ||
Yeast   553 ATNHFYHHFPQQGHHTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVTKER 617

  Fly   196 GYLCTFGNCEKIYAKPAHLKAHL------------RRHLGEKPYVCSWPDCVWRFSRSDELARHK 248
                          :|::.:..:            .:.|.|||:.|.  .|...|.||:.|.||.
Yeast   618 --------------RPSYRRKSMTPSRRSSVVIESTKELEEKPFHCH--ICPKSFKRSEHLKRHV 666

  Fly   249 RS-HSGVKPYKCDYCSKCFARSDHLTKHRKVHER 281
            || ||..:|:.|..|.|.|:|||:|::|.|.|::
Yeast   667 RSVHSNERPFACHICDKKFSRSDNLSQHIKTHKK 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	27/91 (30%)
		C2H2 Zn finger	203..221	CDD:275368	1/29 (3%)
		C2H2 Zn finger	229..251	CDD:275368	10/22 (45%)
		zf-H2C2_2	243..268	CDD:290200	12/25 (48%)
		C2H2 Zn finger	259..279	CDD:275368	10/19 (53%)
MSN2	NP_013751.1	COG5048	127..594	CDD:227381	32/170 (19%)
		zf-C2H2_4	647..670	CDD:404733	10/24 (42%)
		C2H2 Zn finger	649..670	CDD:275368	10/22 (45%)
		zf-H2C2_2	661..687	CDD:404364	12/25 (48%)
		zf-C2H2	676..698	CDD:395048	10/21 (48%)
		C2H2 Zn finger	678..698	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030