DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and ZNF85

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	XP_011526565.1	Gene:	ZNF85 / 7639	HGNCID:	13160	Length:	640	Species:	Homo sapiens

Alignment Length:	151	Identity:	50/151 - (33%)
Similarity:	70/151 - (46%)	Gaps:	16/151 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PLCTDNCADFLEESNSNLRLSGPPHSEIFVPDRSSSSPGSSDSASPAEAVAPPSALQMSENA-AG 193
            |...:.|.....:| |||......|:|        ..|...:..  .:....||.|.:.:.. .|
Human   498 PYECEKCGKAFNQS-SNLTRHKKSHTE--------EKPYKCEEC--GKGFKWPSTLTIHKIIHTG 551

  Fly   194 ERGYLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPYK 258
            |:.|.|.  .|.|.:.:.:.|..|.:.|.|||||.|.  :|...|::|..|.:|||.|:|.||||
Human   552 EKPYKCE--ECGKAFNQSSKLTKHKKIHTGEKPYTCE--ECGKAFNQSSNLTKHKRIHTGEKPYK 612

  Fly   259 CDYCSKCFARSDHLTKHRKVH 279
            |:.|.|.|..|..||||:.:|
Human   613 CEECDKAFKWSSVLTKHKIIH 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	34/78 (44%)
		C2H2 Zn finger	203..221	CDD:275368	4/17 (24%)
		C2H2 Zn finger	229..251	CDD:275368	8/21 (38%)
		zf-H2C2_2	243..268	CDD:290200	14/24 (58%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
ZNF85	XP_011526565.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	189..603	CDD:227381	32/119 (27%)
		C2H2 Zn finger	221..241	CDD:275368
		C2H2 Zn finger	249..269	CDD:275368
		zf-H2C2_2	262..286	CDD:290200
		C2H2 Zn finger	277..297	CDD:275368
		zf-H2C2_2	289..314	CDD:290200
		C2H2 Zn finger	305..325	CDD:275368
		zf-H2C2_2	318..342	CDD:290200
		C2H2 Zn finger	333..353	CDD:275368
		zf-H2C2_2	346..370	CDD:290200
		C2H2 Zn finger	361..381	CDD:275368
		zf-H2C2_2	373..398	CDD:290200
		C2H2 Zn finger	389..409	CDD:275368
		zf-H2C2_2	401..426	CDD:290200
		C2H2 Zn finger	417..437	CDD:275368
		zf-H2C2_2	429..454	CDD:290200
		C2H2 Zn finger	445..465	CDD:275368
		zf-H2C2_2	458..482	CDD:290200
		C2H2 Zn finger	473..493	CDD:275368
		zf-H2C2_2	486..510	CDD:290200	2/11 (18%)
		C2H2 Zn finger	501..521	CDD:275368	5/20 (25%)
		zf-H2C2_2	513..537	CDD:290200	5/33 (15%)
		C2H2 Zn finger	529..549	CDD:275368	3/21 (14%)
		zf-H2C2_2	542..566	CDD:290200	7/25 (28%)
		C2H2 Zn finger	557..577	CDD:275368	5/21 (24%)
		zf-H2C2_2	570..594	CDD:290200	11/25 (44%)
		C2H2 Zn finger	585..605	CDD:275368	8/21 (38%)
		zf-H2C2_2	597..621	CDD:290200	13/23 (57%)
		C2H2 Zn finger	613..633	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000