DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and klf11a

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	XP_021324131.1	Gene:	klf11a / 560787	ZFINID:	ZDB-GENE-030131-3568	Length:	479	Species:	Danio rerio

Alignment Length:	260	Identity:	77/260 - (29%)
Similarity:	114/260 - (43%)	Gaps:	66/260 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SNNNTNTNGNIQV------------GLPHVEDPSLFIDFNDLTV------CPPDLS-----DWEQ 109
            :.:||:..|.:|:            ..|..:...:.|..:..|:      .||.|.     :.:.
Zfish   200 TESNTSLKGEVQICSSPCDSAEPERTAPSPDSTGIAIPTSQSTIPQSPMSSPPVLCQVFPVNGQT 264

  Fly   110 RLLDNYVEIPDLVD------FLPERTPLCTDNCADFLEESNSNLRLSGPPHSE---IFVPDRSSS 165
            .::..:|:.|..:.      .||...||                 |.|.|.::   :||..:|..
Zfish   265 GIISAFVQTPVQMQTSGSKPILPHSQPL-----------------LVGSPVAQGTVMFVVPQSQV 312

  Fly   166 SPGSSDSAS-------------PAEAVAP---PSALQMSENAAGERGYLCTFGNCEKIYAKPAHL 214
            |..|:...|             ||....|   .|.:..|: .:..|.|:|.|..|:|.|.|.:||
Zfish   313 SQSSTCQQSVVTLGNTKLLPLAPAPVYVPSGQSSGVTQSD-FSRRRNYVCNFQGCKKTYFKSSHL 376

  Fly   215 KAHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVH 279
            |||||.|.||||:.|.|..|..:|:|||||:||:|:|:|.|.:.|..|.:.|.||||||||.:.|
Zfish   377 KAHLRTHTGEKPFSCHWEGCDKKFARSDELSRHRRTHTGEKKFVCPVCERRFMRSDHLTKHARRH 441

Fly 280 279
Zfish 442 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	44/78 (56%)
		C2H2 Zn finger	203..221	CDD:275368	11/17 (65%)
		C2H2 Zn finger	229..251	CDD:275368	12/21 (57%)
		zf-H2C2_2	243..268	CDD:290200	11/24 (46%)
		C2H2 Zn finger	259..279	CDD:275368	11/19 (58%)
klf11a	XP_021324131.1	MotB_plug	<203..345	CDD:330912	28/158 (18%)
		C2H2 Zn finger	361..383	CDD:275368	13/21 (62%)
		zf-H2C2_2	375..402	CDD:316026	16/26 (62%)
		C2H2 Zn finger	391..413	CDD:275368	12/21 (57%)
		zf-H2C2_2	405..428	CDD:316026	10/22 (45%)
		zf-C2H2	419..441	CDD:306579	11/21 (52%)
		C2H2 Zn finger	421..441	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940