DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and Klf2

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001007685.1	Gene:	Klf2 / 306330	RGDID:	1359220	Length:	351	Species:	Rattus norvegicus

Alignment Length:	171	Identity:	67/171 - (39%)
Similarity:	86/171 - (50%)	Gaps:	40/171 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 RLSGP----PHSEIFVPDRSSSSPGSS--------------DSASPAEAVAPP----------SA 184
            ||..|    |....|.|..|...||.:              |.|:.|..:|||          |.
  Rat   181 RLPAPGPRNPFPPPFGPGPSFGGPGPALHYGPPAPGAFGLFDDAAAALGLAPPATRGLLTPPSSP 245

  Fly   185 LQMSENAAGERG-----------YLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRF 238
            |::.| |..:||           :.|::.||.|.|.|.:|||||||.|.|||||.|:|..|.|:|
  Rat   246 LELLE-AKPKRGRRSWPRKRAATHTCSYTNCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKF 309

  Fly   239 SRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVH 279
            :|||||.||.|.|:|.:|::|..|.:.|:|||||..|.|.|
  Rat   310 ARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRH 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	44/78 (56%)
		C2H2 Zn finger	203..221	CDD:275368	12/17 (71%)
		C2H2 Zn finger	229..251	CDD:275368	13/21 (62%)
		zf-H2C2_2	243..268	CDD:290200	11/24 (46%)
		C2H2 Zn finger	259..279	CDD:275368	10/19 (53%)
Klf2	NP_001007685.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..110
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:Q9Y5W3	42..50
		Interaction with WWP1. /evidence=ECO:0000250	110..264		21/83 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..209		9/27 (33%)
		COG5048	<266..346	CDD:227381	43/79 (54%)
		zf-C2H2	268..292	CDD:278523	13/23 (57%)
		C2H2 Zn finger	270..292	CDD:275368	13/21 (62%)
		zf-H2C2_2	284..>306	CDD:290200	15/21 (71%)
		C2H2 Zn finger	300..322	CDD:275368	13/21 (62%)
		zf-H2C2_2	314..339	CDD:290200	11/24 (46%)
		C2H2 Zn finger	330..350	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910