DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and wt1a

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_571121.1	Gene:	wt1a / 30245	ZFINID:	ZDB-GENE-980526-558	Length:	419	Species:	Danio rerio

Alignment Length:	294	Identity:	85/294 - (28%)
Similarity:	119/294 - (40%)	Gaps:	90/294 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 STYVDTSFSGGN--YNQLEFEESDYYG-------------------IITLDSNNNTNTNGNIQVG 81
            |..:|:..|..|  |..:.|:.:..||                   .||..||     .|:.|..
Zfish   120 SNCMDSQSSSRNQGYGTVAFDGASNYGHTPSHHTPQFPNHSFKHEDSITQQSN-----MGDQQYP 179

  Fly    82 LPHVEDPSLFIDFNDLTVC--PPDLSDWEQRLLDNYVEIPDLVDFLPERTPLCTDNCADFLEESN 144
            :|    |.::       .|  |.|.....|.||              .|.|.   |.:|.|.:..
Zfish   180 VP----PPVY-------GCHTPSDSCTGSQALL--------------LRNPY---NSSDNLYQMA 216

  Fly   145 SNLRLSG--PPHSEIFVPDRSSSSPG--SSDSASP-------------------------AEAVA 180
            |.|...|  |.:|   :.....|.||  .||.::|                         ...:.
Zfish   217 SQLECMGWNPVNS---LASTIKSHPGGYESDPSTPMVYSCSTQYRIHTHGVFRGLQDVRRVPGIT 278

  Fly   181 PPSALQMSENAAGERGYLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRFSRSDELA 245
            |  |:..|.....:|.::|.:..|.|.|.|.:||:.|.|:|.|||||.|.:.||..||||||:|.
Zfish   279 P--AIVRSTETNEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFTDCGRRFSRSDQLK 341

  Fly   246 RHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVH 279
            ||:|.|:||||::|:.|.:.|:|||||..|.:.|
Zfish   342 RHQRRHTGVKPFQCETCQRKFSRSDHLKTHTRTH 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	42/78 (54%)
		C2H2 Zn finger	203..221	CDD:275368	8/17 (47%)
		C2H2 Zn finger	229..251	CDD:275368	13/21 (62%)
		zf-H2C2_2	243..268	CDD:290200	12/24 (50%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
wt1a	NP_571121.1	WT1	1..291	CDD:280348	41/208 (20%)
		COG5048	286..>411	CDD:227381	44/90 (49%)
		C2H2 Zn finger	298..317	CDD:275368	8/18 (44%)
		zf-H2C2_2	309..336	CDD:290200	15/26 (58%)
		C2H2 Zn finger	325..347	CDD:275368	13/21 (62%)
		zf-H2C2_2	340..364	CDD:290200	12/23 (52%)
		C2H2 Zn finger	355..375	CDD:275368	9/19 (47%)
		C2H2 Zn finger	386..408	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000