DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Klf15 and egr2b

DIOPT Version :9

Sequence 1:NP_572185.1 Gene:Klf15 / 31410 FlyBaseID:FBgn0025679 Length:311 Species:Drosophila melanogaster
Sequence 2:NP_571072.2 Gene:egr2b / 30190 ZFINID:ZDB-GENE-980526-283 Length:412 Species:Danio rerio


Alignment Length:376 Identity:95/376 - (25%)
Similarity:140/376 - (37%) Gaps:115/376 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LYSDL--EEEPLAGGDALLNIVSVGEF--DSTYVDTSFS------GGNYNQLEFEESDYYGIITL 66
            :|:||  ..|.:..||.|:|    |:.  :...:|.::|      .|..||    ...|.|..::
Zfish    40 IYNDLGGHYEQINAGDGLIN----GDMSTEKRALDLAYSSSFAQPAGPRNQ----TFTYMGKFSI 96

  Fly    67 DSN--NNTNTNGNI----------------------------------------QVGLPHV---- 85
            ||.  .|.|..|.|                                        |..:.|:    
Zfish    97 DSQYPGNWNPEGVINIVSAGILGMTQPSSASSSPASSVSPSHFSSTLSCTMAQNQADMEHIYSPP 161

  Fly    86 ----------EDPSLFIDFNDLTVC--PPDLSDWEQRLLDN--YVEIPDLVDF-----------L 125
                      :|||.|:..:...:.  ||..|..:.. .|:  :..|||...|           :
Zfish   162 PPYSGCGEVYQDPSAFLSTSTCPISYPPPSYSSPKPN-ADSGLFPIIPDYAGFFQPPCQRDMQSM 225

  Fly   126 PERTPLCTDNCA--DF-----LEESNS--NLRLSGPPHSEIFVPDRSSSSPGSSDSASPAEAVAP 181
            |:|.|.   :|.  .|     |...|:  |..|.||      |||........:....|...:..
Zfish   226 PDRKPF---SCPLDSFKLPPPLTPLNTIRNFTLGGP------VPDGPRLPTAYTPQNLPLRPILR 281

  Fly   182 PSAL--QMSENAAGERGYLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRFSRSDEL 244
            |...  :.|:....||.|.|....|::.:::...|..|:|.|.|.||:.|.  .|:..|||||.|
Zfish   282 PRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCR--ICMRNFSRSDHL 344

  Fly   245 ARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVHER---RLLAASRAGRS 292
            ..|.|:|:|.||:.||:|.:.|||||...:|.|:|.|   |..::|..|.|
Zfish   345 TTHIRTHTGEKPFACDFCGRKFARSDERKRHTKIHLRQKERKSSSSSTGVS 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klf15NP_572185.1 zf-C2H2_8 199..278 CDD:292531 32/78 (41%)
C2H2 Zn finger 203..221 CDD:275368 4/17 (24%)
C2H2 Zn finger 229..251 CDD:275368 10/21 (48%)
zf-H2C2_2 243..268 CDD:290200 11/24 (46%)
C2H2 Zn finger 259..279 CDD:275368 10/19 (53%)
egr2bNP_571072.2 DUF3446 92..164 CDD:288757 9/71 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..299 5/29 (17%)
COG5048 295..>357 CDD:227381 25/63 (40%)
zf-C2H2 299..323 CDD:278523 6/23 (26%)
C2H2 Zn finger 301..323 CDD:275368 5/21 (24%)
zf-H2C2_2 315..340 CDD:290200 10/26 (38%)
COG5048 327..>411 CDD:227381 32/71 (45%)
C2H2 Zn finger 331..351 CDD:275368 10/21 (48%)
zf-H2C2_2 343..368 CDD:290200 11/24 (46%)
C2H2 Zn finger 359..379 CDD:275368 10/19 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 371..412 8/25 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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