DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and EGR3

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	XP_005273482.1	Gene:	EGR3 / 1960	HGNCID:	3240	Length:	442	Species:	Homo sapiens

Alignment Length:	324	Identity:	77/324 - (23%)
Similarity:	124/324 - (38%)	Gaps:	94/324 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NIVSVG-EFDSTYVDTSFSG------GNYNQLEFEESDYYGIITLDSNNN--------------- 71
            |::.:| ..:....:.|:||      ||      :...|.|....||.:|
Human   108 NVMDIGLTNEKPNPELSYSGSFQPAPGN------KTVTYLGKFAFDSPSNWCQDNIISLMSAGIL 166

  Fly    72 ------------TNT-------NGNIQVGLPHVEDPS----LF---IDFND------LTVCPPDL 104
                        |:|       .|:::...|.:...|    |:   :.|:|      |...|.|.
Human   167 GVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDY 231

  Fly   105 SDWEQRLLDN-YVEIPDL--------VDFLPERTPLCTDNCADFLEESNSNLRLSGPPHSEI--- 157
            ...:..|..| :..|||.        :..:||..|.          :....:|::.||.:.:
Human   232 QSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPF----------QGMDPIRVNPPPITPLETI 286

  Fly   158 -FVPDRSSSSPGSSDSASPAEAVAP------PSALQMSENAAGERGYLCTFGNCEKIYAKPAHLK 215
             ...|: ...||......|...:.|      |:  :.|:....||.:.|....|::.:::...|.
Human   287 KAFKDK-QIHPGFGSLPQPPLTLKPIRPRKYPN--RPSKTPLHERPHACPAEGCDRRFSRSDELT 348

  Fly   216 AHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVH 279
            .|||.|.|.||:.|.  .|:..|||||.|..|.|:|:|.||:.|::|.:.|||||...:|.|:|
Human   349 RHLRIHTGHKPFQCR--ICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIH 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	32/78 (41%)
		C2H2 Zn finger	203..221	CDD:275368	5/17 (29%)
		C2H2 Zn finger	229..251	CDD:275368	10/21 (48%)
		zf-H2C2_2	243..268	CDD:290200	10/24 (42%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
EGR3	XP_005273482.1	DUF3446	142..202	CDD:288757	8/59 (14%)
		COG5048	324..>388	CDD:227381	25/65 (38%)
		zf-C2H2	330..354	CDD:278523	6/23 (26%)
		C2H2 Zn finger	332..354	CDD:275368	6/21 (29%)
		zf-H2C2_2	346..371	CDD:290200	11/26 (42%)
		COG5048	358..>431	CDD:227381	26/55 (47%)
		C2H2 Zn finger	362..382	CDD:275368	10/21 (48%)
		zf-H2C2_2	374..399	CDD:290200	10/24 (42%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940