DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and EGR1

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001955.1	Gene:	EGR1 / 1958	HGNCID:	3238	Length:	543	Species:	Homo sapiens

Alignment Length:	229	Identity:	70/229 - (30%)
Similarity:	101/229 - (44%)	Gaps:	41/229 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GNIQVGLPHVEDPSLFIDFNDLTVCPPDLSDWEQRLLDNYVEIPDLVDFLPERTPLCTDNCADFL 140
            |..||  |.:.|........||.:..||...::.  |::..:.|.|       |||.|...  |.
Human   245 GGFQV--PMIPDYLFPQQQGDLGLGTPDQKPFQG--LESRTQQPSL-------TPLSTIKA--FA 296

  Fly   141 EESNS-NLR-LSGPPHSEIFVPDRSSSSPGSSDSASPAEAVAPPSALQMSENAAGERGYLCTFGN 203
            .:|.| :|: |:....|::..|.|....|.......|                 .||.|.|...:
Human   297 TQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPP-----------------HERPYACPVES 344

  Fly   204 CEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPYKCDYCSKCFAR 268
            |::.:::...|..|:|.|.|:||:.|.  .|:..|||||.|..|.|:|:|.||:.||.|.:.|||
Human   345 CDRRFSRSDELTRHIRIHTGQKPFQCR--ICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFAR 407

  Fly   269 SDHLTKHRKVHER-------RLLAASRAGRSLIS 295
            ||...:|.|:|.|       :.:.||.|..||.|
Human   408 SDERKRHTKIHLRQKDKKADKSVVASSATSSLSS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	32/78 (41%)
		C2H2 Zn finger	203..221	CDD:275368	4/17 (24%)
		C2H2 Zn finger	229..251	CDD:275368	10/21 (48%)
		zf-H2C2_2	243..268	CDD:290200	11/24 (46%)
		C2H2 Zn finger	259..279	CDD:275368	10/19 (53%)
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105
		DUF3446	135..209	CDD:314753
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..284		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..339		6/37 (16%)
		zf-C2H2	338..362	CDD:306579	6/23 (26%)
		C2H2 Zn finger	340..362	CDD:275368	5/21 (24%)
		zf-H2C2_2	354..379	CDD:316026	10/26 (38%)
		C2H2 Zn finger	370..390	CDD:275368	10/21 (48%)
		zf-H2C2_2	382..407	CDD:316026	11/24 (46%)
		C2H2 Zn finger	398..418	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..487		11/33 (33%)
		DUF3432	447..530	CDD:288743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940