DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and Egr3

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_061251.1	Gene:	Egr3 / 13655	MGIID:	1306780	Length:	387	Species:	Mus musculus

Alignment Length:	380	Identity:	88/380 - (23%)
Similarity:	134/380 - (35%)	Gaps:	132/380 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QLYSDL--EEEPLAGGDALLNIVSVGEFDSTYVDTSFSGGNYNQLEFEE---------------- 57
            ||..:|  ||.|.|     ||:.| |..||.        .:|||:..|.
Mouse    19 QLPDNLYPEEIPSA-----LNLFS-GSSDSV--------AHYNQMATENVMDIGLTNEKPNPELS 69

  Fly    58 -------------SDYYGIITLDSNNN---------------------------TNT-------N 75
                         ..|.|....||.:|                           |:|       .
Mouse    70 YSSSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQ 134

  Fly    76 GNIQVGLPHV----------EDPSLFIDFND------LTVCPPDLSDWEQRLLDN-YVEIPDL-- 121
            |:::...|.:          .:|   :.|:|      |...|.|....:..|..| :..|||.
Mouse   135 GDVEAMYPALPPYSNCGDLYSEP---VSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNL 196

  Fly   122 ------VDFLPERTPLCTDNCADFLEESNSNLRLSGPPHSEI----FVPDRSSSSPGSSDSASPA 176
                  :..:||..|.          :....:|::.||.:.:    ...|: ...||......|.
Mouse   197 YHHPNDMGSIPEHKPF----------QGMDPIRVNPPPITPLETIKAFKDK-QIHPGFGSLPQPP 250

  Fly   177 EAVAP------PSALQMSENAAGERGYLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCV 235
            ..:.|      |:  :.|:....||.:.|....|::.:::...|..|||.|.|.||:.|.  .|:
Mouse   251 LTLKPIRPRKYPN--RPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCR--ICM 311

  Fly   236 WRFSRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVHERRLLAASRAG 290
            ..|||||.|..|.|:|:|.||:.|::|.:.|||||...:|.|:|.::....|..|
Mouse   312 RSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKSEKG 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	32/78 (41%)
		C2H2 Zn finger	203..221	CDD:275368	5/17 (29%)
		C2H2 Zn finger	229..251	CDD:275368	10/21 (48%)
		zf-H2C2_2	243..268	CDD:290200	10/24 (42%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
Egr3	NP_061251.1	DUF3446	87..147	CDD:314753	8/59 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..283		9/43 (21%)
		COG5048	269..>333	CDD:227381	25/65 (38%)
		C2H2 Zn finger	277..299	CDD:275368	6/21 (29%)
		COG5048	303..>375	CDD:227381	28/66 (42%)
		C2H2 Zn finger	307..327	CDD:275368	10/21 (48%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..387		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940