DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klf15 and KLF14

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_619638.2	Gene:	KLF14 / 136259	HGNCID:	23025	Length:	323	Species:	Homo sapiens

Alignment Length:	217	Identity:	70/217 - (32%)
Similarity:	98/217 - (45%)	Gaps:	40/217 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PHVEDPSLFIDFNDLTVCPPDLSDWEQRLLDNYVEIPDLVDFLPERTPLCTDN-CADFLEESNSN 146
            ||:...|::.|....:    ....||     |..|.|.......:..|..... |::....|.:
Human    81 PHLLAASVWADLRGSS----GEGSWE-----NSGEAPRASSGFSDPIPCSVQTPCSELAPASGA- 135

  Fly   147 LRLSGPPHSEIFVPDRSSSSP-------------------GSSDSASPAEAVAPPSALQMSENAA 192
                    :.:..|:.||.:|                   |.:..|.||.| |..:..:.|...|
Human   136 --------AAVCAPESSSDAPAVPSAPAAPGAPAASGGFSGGALGAGPAPA-ADQAPRRRSVTPA 191

  Fly   193 GERGYLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPY 257
            .:| :.|.|..|.|.|.|.:|||:|.|.|.||:|:.|.|.||..:|:||||||||.|:|:|.|.:
Human   192 AKR-HQCPFPGCTKAYYKSSHLKSHQRTHTGERPFSCDWLDCDKKFTRSDELARHYRTHTGEKRF 255

  Fly   258 KCDYCSKCFARSDHLTKHRKVH 279
            .|..|.|.|:||||||||.:.|
Human   256 SCPLCPKQFSRSDHLTKHARRH 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	44/78 (56%)
		C2H2 Zn finger	203..221	CDD:275368	9/17 (53%)
		C2H2 Zn finger	229..251	CDD:275368	14/21 (67%)
		zf-H2C2_2	243..268	CDD:290200	13/24 (54%)
		C2H2 Zn finger	259..279	CDD:275368	12/19 (63%)
KLF14	NP_619638.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..80
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..116		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..161		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..195		9/30 (30%)
		COG5048	198..>283	CDD:227381	44/80 (55%)
		C2H2 Zn finger	200..219	CDD:275368	9/18 (50%)
		C2H2 Zn finger	227..249	CDD:275368	14/21 (67%)
		C2H2 Zn finger	257..277	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840