DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klf15 and KLF17

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_775755.3	Gene:	KLF17 / 128209	HGNCID:	18830	Length:	389	Species:	Homo sapiens

Alignment Length:	283	Identity:	93/283 - (32%)
Similarity:	125/283 - (44%)	Gaps:	45/283 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QQLYSDLEEEPLAGGDALLNIVSVGEFDSTYVDTSFSGGNY----NQLEFEESDYYGIITLDSNN 70
            |::....:|..:..|..|:   .|||.:...|...| |||.    |.|....|.  ||..:....
Human   115 QRMSPPQQEMTIFSGPQLM---PVGEPNIPRVARPF-GGNLRMPPNGLPVSAST--GIPIMSHTG 173

  Fly    71 NTNTNGNIQVGLPHVEDPSLFIDFNDLTVCPPDLSDWEQRLLDNYVEIPDLVDFLPERTPLCTDN 135
            |           |.|..|.|....:|.|:..|.:...|.:.:     :|.:...||   |....:
Human   174 N-----------PPVPYPGLSTVPSDETLLGPTVPSTEAQAV-----LPSMAQMLP---PQDAHD 219

  Fly   136 CADFLEESNSNLRLSGPPHSEIFVPDRSSSSPGSSDSASPAEAVAPPSALQMS---ENAAGERG- 196
            ......||.|.|.| |...|.:..|| |...|...:...||     |..::.:   :...|.||
Human   220 LGMPPAESQSLLVL-GSQDSLVSQPD-SQEGPFLPEQPGPA-----PQTVEKNSRPQEGTGRRGS 277

  Fly   197 -----YLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKP 256
                 |.|.:.||.|.|.|.:||.:|.|:|.||:||.|:|..|.|.|.|||||.||.|.|:..:|
Human   278 SEARPYCCNYENCGKAYTKRSHLVSHQRKHTGERPYSCNWESCSWSFFRSDELRRHMRVHTRYRP 342

  Fly   257 YKCDYCSKCFARSDHLTKHRKVH 279
            ||||.||:.|.|||||.:|:|.|
Human   343 YKCDQCSREFMRSDHLKQHQKTH 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	43/78 (55%)
		C2H2 Zn finger	203..221	CDD:275368	9/17 (53%)
		C2H2 Zn finger	229..251	CDD:275368	13/21 (62%)
		zf-H2C2_2	243..268	CDD:290200	14/24 (58%)
		C2H2 Zn finger	259..279	CDD:275368	12/19 (63%)
KLF17	NP_775755.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..279		10/45 (22%)
		COG5048	282..>350	CDD:227381	36/67 (54%)
		zf-C2H2	283..307	CDD:278523	11/23 (48%)
		C2H2 Zn finger	285..307	CDD:275368	10/21 (48%)
		zf-C2H2	313..337	CDD:278523	14/23 (61%)
		C2H2 Zn finger	315..337	CDD:275368	13/21 (62%)
		zf-H2C2_2	329..352	CDD:290200	13/22 (59%)
		zf-C2H2	343..365	CDD:278523	14/21 (67%)
		C2H2 Zn finger	345..365	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..389		6/10 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.800