DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klf15 and KLF12

DIOPT Version :9

Sequence 1:NP_572185.1 Gene:Klf15 / 31410 FlyBaseID:FBgn0025679 Length:311 Species:Drosophila melanogaster
Sequence 2:XP_011533209.1 Gene:KLF12 / 11278 HGNCID:6346 Length:415 Species:Homo sapiens


Alignment Length:370 Identity:97/370 - (26%)
Similarity:136/370 - (36%) Gaps:121/370 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 YSDLEEEPLAGGDALLNIVSVGE--FDSTYVD--------------------------------- 42
            |.|:|..||     |||.|. ||  .||..||                                 
Human    61 YPDMEAVPL-----LLNNVK-GEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTAS 119

  Fly    43 ------TSFSGGNYNQLEFEESDYYGIITLDSNNNTNTNGNIQVGLP--------HVEDPSLFID 93
                  ||.|..:.::|....:....:.:..|::...|.|.:.....        |:..|     
Human   120 ASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHP----- 179

  Fly    94 FNDLTVCPPDLSDWEQRLLDNYVEIPDLVDFLP-----ERTPLCTDN--CADFLEESNSNLRLSG 151
                 |.|....:.:...|.:...||.:|..:|     .|:|...:|  ....||:...:.:...
Human   180 -----VPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQM 239

  Fly   152 PPHSEIFVPDRSSSSPGSSD---------------SASPAEAV-----APPSALQ---------- 186
            .|..  ..|.:|.|.....|               :.|.|.||     :|.|.::          
Human   240 DPRG--LSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFP 302

  Fly   187 -----------------MSENAAGERGYLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDC 234
                             .|.::...|.:.|.|..|.|:|.|.:|||||.|.|.|||||.|:|..|
Human   303 CSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGC 367

  Fly   235 VWRFSRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVH 279
            .|:|:|||||.||.|.|:||||:||..|.:.|:|||||..||:.|
Human   368 TWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRH 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klf15NP_572185.1 zf-C2H2_8 199..278 CDD:292531 47/78 (60%)
C2H2 Zn finger 203..221 CDD:275368 10/17 (59%)
C2H2 Zn finger 229..251 CDD:275368 13/21 (62%)
zf-H2C2_2 243..268 CDD:290200 14/24 (58%)
C2H2 Zn finger 259..279 CDD:275368 10/19 (53%)
KLF12XP_011533209.1 COG5048 <241..414 CDD:227381 61/174 (35%)
zf-C2H2 330..354 CDD:278523 12/23 (52%)
C2H2 Zn finger 332..354 CDD:275368 12/21 (57%)
zf-H2C2_2 346..>363 CDD:290200 12/16 (75%)
C2H2 Zn finger 362..384 CDD:275368 13/21 (62%)
zf-H2C2_2 376..401 CDD:290200 14/24 (58%)
C2H2 Zn finger 392..412 CDD:275368 10/19 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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