DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klf15 and KLF2

DIOPT Version :9

Sequence 1:NP_572185.1 Gene:Klf15 / 31410 FlyBaseID:FBgn0025679 Length:311 Species:Drosophila melanogaster
Sequence 2:NP_057354.1 Gene:KLF2 / 10365 HGNCID:6347 Length:355 Species:Homo sapiens


Alignment Length:195 Identity:70/195 - (35%)
Similarity:92/195 - (47%) Gaps:52/195 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 PERTPLCTDNCADFLEESNSNLRLSGPPHSEIFVPDRSS---SSPGS---------------SDS 172
            |:..||..|..|          ||..|.....|.|....   .:||.               .|:
Human   171 PDTPPLSPDGPA----------RLPAPGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDA 225

  Fly   173 ASPAEA--VAPPSA----------LQMSENAAGERG-----------YLCTFGNCEKIYAKPAHL 214
            |:.|.|  :|||:|          |::.| |..:||           :.|::..|.|.|.|.:||
Human   226 AAAAAALGLAPPAARGLLTPPASPLELLE-AKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHL 289

  Fly   215 KAHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVH 279
            |||||.|.|||||.|:|..|.|:|:|||||.||.|.|:|.:|::|..|.:.|:|||||..|.|.|
Human   290 KAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRH 354

  Fly   280  279
            Human   355  354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klf15NP_572185.1 zf-C2H2_8 199..278 CDD:292531 43/78 (55%)
C2H2 Zn finger 203..221 CDD:275368 11/17 (65%)
C2H2 Zn finger 229..251 CDD:275368 13/21 (62%)
zf-H2C2_2 243..268 CDD:290200 11/24 (46%)
C2H2 Zn finger 259..279 CDD:275368 10/19 (53%)
KLF2NP_057354.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 43..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..90
Interaction with WWP1. /evidence=ECO:0000250 111..268 25/107 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..209 12/47 (26%)
COG5048 <267..350 CDD:227381 42/82 (51%)
zf-C2H2 272..296 CDD:278523 12/23 (52%)
C2H2 Zn finger 274..296 CDD:275368 12/21 (57%)
zf-H2C2_2 288..>310 CDD:290200 15/21 (71%)
C2H2 Zn finger 304..326 CDD:275368 13/21 (62%)
zf-H2C2_2 318..343 CDD:290200 11/24 (46%)
C2H2 Zn finger 334..354 CDD:275368 10/19 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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