DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klf15 and klf5a

DIOPT Version :9

Sequence 1:	NP_572185.1	Gene:	Klf15 / 31410	FlyBaseID:	FBgn0025679	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	XP_001344916.5	Gene:	klf5a / 100006043	ZFINID:	ZDB-GENE-090312-167	Length:	429	Species:	Danio rerio

Alignment Length:	304	Identity:	86/304 - (28%)
Similarity:	129/304 - (42%)	Gaps:	90/304 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EFDSTYVDTSFSGGNYNQLEFEESDYYGIITLDSNNNTNTNGNIQVGLPHVEDPSLFIDFNDLTV 99
            :|.|.:...|.||.             |:..:|.:........:| |....:|..||
Zfish   157 DFTSIFNSNSTSGS-------------GMDVVDDSAGVFVKQEMQ-GFDIPQDGPLF-------- 199

  Fly   100 CPPDLSDWEQRLLDNYVEIPDLVD--------------FLPERT-------------PLCTDNCA 137
                      :||::.:::||..|              ...::|             ||...:..
Zfish   200 ----------QLLNSELDVPDPTDPHAHSQMPTFHNLHLAAQQTAAKSYCGMAAHGYPLSHGHFV 254

  Fly   138 DFLEESNSNLRLS----GPPHSEIFVPDRSSS-----SPGSSDSASPAEAVA------------- 180
            ...::::|.|:::    .||.||...|||...     :|..|.:|:.|..:|
Zfish   255 HPQDQAHSQLKMTYLPPSPPTSEPGSPDRQKELLHNLTPPPSYAATIASKMAGHAPSHPTPASAR 319

  Fly   181 PPSAL---------QMSENAAGERGYLCTFGNCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVW 236
            ||:..         :.:.:....|.:.|.|..|:|:|.|.:|||||||.|.|||||.|:|..|.|
Zfish   320 PPTTTGSMPVRYNRRTNPDLEKRRIHHCDFPGCKKVYTKSSHLKAHLRTHTGEKPYRCTWEGCDW 384

  Fly   237 RFSRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVHE 280
            ||:|||||.||.|.|:|.||::|..||:.|:|||||..|.|.|:
Zfish   385 RFARSDELTRHFRKHTGAKPFQCAVCSRSFSRSDHLALHMKRHQ 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf15	NP_572185.1	zf-C2H2_8	199..278	CDD:292531	47/78 (60%)
		C2H2 Zn finger	203..221	CDD:275368	11/17 (65%)
		C2H2 Zn finger	229..251	CDD:275368	14/21 (67%)
		zf-H2C2_2	243..268	CDD:290200	13/24 (54%)
		C2H2 Zn finger	259..279	CDD:275368	11/19 (58%)
klf5a	XP_001344916.5	COG5048	322..>408	CDD:227381	38/85 (45%)
		C2H2 Zn finger	350..369	CDD:275368	11/18 (61%)
		zf-H2C2_2	361..>378	CDD:290200	13/16 (81%)
		C2H2 Zn finger	377..399	CDD:275368	14/21 (67%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..427	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4706
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960