Protein Alignment Proc-R and GPR18

DIOPT Version :9

• Sequence 1: NP_001014723.1
• Gene: Proc-R / 31408
• FlyBaseID: FBgn0029723
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_001091670.1
• Gene: GPR18 / 2841
• HGNCID: 4472
• Length: 331
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 87/496 - (17%)
• Similarity: 161/496 - (32%)
• Gaps: 210/496 - (42%)

  Fly    45 ILVPCVFVIGLLGNSVSIYVL--TRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF 107
            :...|:|:|||..|..:::|.  |.|: |.|..||:..:|:.|:.::   :.|..:.:    |:.
Human    27 VFYSCIFIIGLFVNITALWVFSCTTKK-RTTVTIYMMNVALVDLIFI---MTLPFRMF----YYA 83

  Fly   108 KLYWQLYGYFVWLCDSFG-------YISIYIAVCFTIERFIAI---RYPLKRQTFCTESLAKKVI 162
            |..|....||   |...|       .|::::....:.:|::||   :|..:.:..|     |.|:
Human    84 KDEWPFGEYF---CQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTC-----KAVL 140

  Fly   163 AAVAIFCLLSTLSTAFEHTITIGTRQIDDAYQPCNQTVANISPMPPPPVAVTPPLATPPLPTPAT 227
            |.|.::  :.||:|                                          |.||   ..
Human   141 ACVGVW--IMTLTT------------------------------------------TTPL---LL 158

  Fly   228 IWQSPDSAMESTTSGSSNQLVDWGSGSGDGEPENIPRHRRHWQSSGFVTLPTLRKTLEEQDQKVA 292
            :::.||.                     |..|..
Human   159 LYKDPDK---------------------DSTPAT------------------------------- 171

  Fly   293 DAAQRSGVTESLLQLWRRKRSAENHNINNTDAFAFNVTEYCQNVTYYNHGLSELGYDELYSYLWN 357
                                                    |..:       |::.|.:..:.| |
Human   172 ----------------------------------------CLKI-------SDIIYLKAVNVL-N 188

  Fly   358 LFTLLVFVVFPLLLLATFNSILILLVHRSKNLRGDLTNASSIRRTKRKSNSGLKGSVSQEN-RVT 421
            |..|..|.:.||.::.   ...::::|..  |.|         ||     |.||..|.::: |:.
Human   189 LTRLTFFFLIPLFIMI---GCYLVIIHNL--LHG---------RT-----SKLKPKVKEKSIRII 234

  Fly   422 ITLIAVVLMFIVCQLPWAIYLIVNQYMEIQIGTQVVA----GNVCNLLASLHAASNFFLYCVLSD 482
            |||:..||   ||.:|:.|.     :..:.:||...:    |.....|.:|....:..||.::|.
Human   235 ITLLVQVL---VCFMPFHIC-----FAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSK 291

  Fly   483 KYRKTVRELITGYRYRRRHARNNTSLYVPHTTTTLTQINGD 523
            :::..|..::....|.|...|.:   :...:..:|:.||.:
Human   292 QFQARVISVMLYRNYLRSMRRKS---FRSGSLRSLSNINSE 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Proc-R	NP_001014723.1	7tm_4	52..>183	CDD:304433	34/142 (24%)
GPR18	NP_001091670.1	7tmA_NAGly_R_GPR18	23..297	CDD:320294	80/459 (17%)
		TM helix 1	23..50	CDD:320294	7/22 (32%)
		TM helix 2	57..82	CDD:320294	5/31 (16%)
		TM helix 3	94..124	CDD:320294	5/29 (17%)
		TM helix 4	136..158	CDD:320294	11/73 (15%)
		TM helix 5	184..213	CDD:320294	7/32 (22%)
		TM helix 6	225..255	CDD:320294	11/37 (30%)
		TM helix 7	265..290	CDD:320294	5/24 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000