DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7024 and PDHA2

DIOPT Version :9

Sequence 1:	NP_572182.1	Gene:	CG7024 / 31407	FlyBaseID:	FBgn0029722	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_005381.1	Gene:	PDHA2 / 5161	HGNCID:	8807	Length:	388	Species:	Homo sapiens

Alignment Length:	378	Identity:	190/378 - (50%)
Similarity:	249/378 - (65%)	Gaps:	13/378 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RVAMRCSGAHSILERNMLCRIIGRHKCSCLTLENTFKC--YDLENGPTMDVELSREDALTMYTQM 70
            |||.:.:       |.:|  :..|:..:..|.| ..||  |.||.||.:...|:|.:.|..|..|
Human    12 RVAQKSA-------RRVL--VASRNSSNDATFE-IKKCDLYLLEEGPPVTTVLTRAEGLKYYRMM 66

  Fly    71 LELRRFETVAGNYYKERKIRGFCHLYNGQEAVAVGMKQRLRSCDSVITAYRCHAWTYLMGVSLYE 135
            |.:||.|..|...||::.|||||||.:||||..||::..:...|.|||:||.|...|..|:|:..
Human    67 LTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHGVCYTRGLSVRS 131

  Fly   136 IMAELFGVRTGCSRGKGGSMHMYSDKFYGGNGIVGAQVPLGAGIGLAHSYRKDNGVSVVLYGDGA 200
            |:|||.|.|.||::|||||||||:..|||||||||||.||||||.||..|:.::.:.:.||||||
Human   132 ILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACKYKGNDEICLTLYGDGA 196

  Fly   201 ANQGQIFESFNMAKLWCLPCIFVCENNHYGMGTHVKRASAMTEFYMRGQYIPGLWVDGNQVLAVR 265
            ||||||.|:||||.||.|||:|:||||.|||||..:||:|..::|.||.:||||.|||..||.||
Human   197 ANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDYYKRGNFIPGLKVDGMDVLCVR 261

  Fly   266 SATQFAVDHALK-HGPIVLEMSTYRYVGHSMSDPGTSYRSREEVQSTREKRDPITSFRSQIIALC 329
            .||:||.::... .|||::|:.||||.||||||||.|||:|||:|..|.|||||...:.:::...
Human   262 EATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKRDPIIILQDRMVNSK 326

  Fly   330 LADEEELKALDDKTRKQVDSICKKATTDREVELDELHTDIYAKNVDGKIRGVS 382
            ||..||||.:..:.||::|...:.||||.|..|:||...||:.:...::||.:
Human   327 LATVEELKEIGAEVRKEIDDAAQFATTDPEPHLEELGHHIYSSDSSFEVRGAN 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7024	NP_572182.1	TPP_enzymes	37..381	CDD:294952	183/346 (53%)
PDHA2	NP_005381.1	PDH_E1_alph_y	56..368	CDD:274473	171/311 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143839
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S510
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D318981at33208
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		mtm8483
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	O	PTHR11516
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.670