DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdha and E1 ALPHA

DIOPT Version :9

Sequence 1:	NP_726945.1	Gene:	Pdha / 31406	FlyBaseID:	FBgn0028325	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_176198.1	Gene:	E1 ALPHA / 842284	AraportID:	AT1G59900	Length:	389	Species:	Arabidopsis thaliana

Alignment Length:	365	Identity:	182/365 - (49%)
Similarity:	238/365 - (65%)	Gaps:	12/365 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 TEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETAAGNLYKEKIIRGFCHLYS 143
            |..|::.:.||..|..|. |:..|:.:..:.|.::..|..:||:|.||.:|||.|:||||||||.
plant    30 TPITIETSLPFTAHLCDP-PSRSVESSSQELLDFFRTMALMRRMEIAADSLYKAKLIRGFCHLYD 93

  Fly   144 GQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMY--AP 206
            ||||.|:||:||:...|.||:|||.|......|.|...|.:||.|.|.||::|||||||.|  ..
plant    94 GQEAVAIGMEAAITKKDAIITAYRDHCIFLGRGGSLHEVFSELMGRQAGCSKGKGGSMHFYKKES 158

  Fly   207 NFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCE 271
            :||||:||||||||||.|:..|.||.....:..||||||||||||:|||.|::.||.||.|.|||
plant   159 SFYGGHGIVGAQVPLGCGIAFAQKYNKEEAVTFALYGDGAANQGQLFEALNISALWDLPAILVCE 223

  Fly   272 NNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNTHGPLVMETNTYRY 336
            ||:|||||:..||:.:..||.|||.:||:.|||||..||:.|.:||..:....||:::|.:||||
plant   224 NNHYGMGTAEWRAAKSPSYYKRGDYVPGLKVDGMDAFAVKQACKFAKQHALEKGPIILEMDTYRY 288

  Fly   337 SGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAK 401
            .||||||||::||||:||..|||:||||...|:|.:...|.|..|:|.::.::|||||:|.|.||
plant   289 HGHSMSDPGSTYRTRDEISGVRQERDPIERIKKLVLSHDLATEKELKDMEKEIRKEVDDAIAKAK 353

  Fly   402 SDAELGVSHLWTDVYSNNLEPKLRGTIAYDIDHIQERKGV 441
            .......|.|:|:||....     ||.::..|    ||.|
plant   354 DCPMPEPSELFTNVYVKGF-----GTESFGPD----RKEV 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	176/348 (51%)
E1 ALPHA	NP_176198.1	PLN02269	28..389	CDD:215152	182/365 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	324	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I637
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D871160at2759
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		mtm1206
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	O	PTHR11516
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840