DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdha and PDH-E1 ALPHA

DIOPT Version :9

Sequence 1:	NP_726945.1	Gene:	Pdha / 31406	FlyBaseID:	FBgn0028325	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_171617.1	Gene:	PDH-E1 ALPHA / 839429	AraportID:	AT1G01090	Length:	428	Species:	Arabidopsis thaliana

Alignment Length:	383	Identity:	133/383 - (34%)
Similarity:	203/383 - (53%)	Gaps:	28/383 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SSFFGLFQNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRR 121
            |||.|..::.:...::.:|.......|.|....|..:....  |.:.:||::.|:.|..|...|.
plant    34 SSFLGSTRSLSLRRLNHSNATRRSPVVSVQEVVKEKQSTNN--TSLLITKEEGLELYEDMILGRS 96

  Fly   122 LETAAGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAEL 186
            .|.....:|....:.||.|||:||||.:.|....:...|:::|.||.|......|||...|::||
plant    97 FEDMCAQMYYRGKMFGFVHLYNGQEAVSTGFIKLLTKSDSVVSTYRDHVHALSKGVSARAVMSEL 161

  Fly   187 TGVQGGCARGKGGSMHMYAP--NFYGGNGIVGAQVPLGAGVGLACKYKGN------GGMCLALYG 243
            .|...||.||:||||||::.  |..||...:|..:|:..|...:.||:..      ..:.:|.:|
plant   162 FGKVTGCCRGQGGSMHMFSKEHNMLGGFAFIGEGIPVATGAAFSSKYRREVLKQDCDDVTVAFFG 226

  Fly   244 DGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDA--LPGIWVDGMD 306
            ||..|.||.||..|||.|:|||:|||.|||.:.:|.|..||:.:.:.:.:|.|  :||:.|||||
plant   227 DGTCNNGQFFECLNMAALYKLPIIFVVENNLWAIGMSHLRATSDPEIWKKGPAFGMPGVHVDGMD 291

  Fly   307 VLAVRSATEFAINYVNT-HGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQK-----RDPIT 365
            ||.||...:.|:..... .||.::|..|||:.|||::||       :|:::..:|     ||||.
plant   292 VLKVREVAKEAVTRARRGEGPTLVECETYRFRGHSLADP-------DELRDAAEKAKYAARDPIA 349

  Fly   366 SFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPK 423
            :.|:..||..|....|:|:|:.|:.:.|:||..||.:..:.|.|.|..:|::   :||
plant   350 ALKKYLIENKLAKEAELKSIEKKIDELVEEAVEFADASPQPGRSQLLENVFA---DPK 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	128/362 (35%)
PDH-E1 ALPHA	NP_171617.1	PLN02374	1..428	CDD:215213	133/383 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D871160at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.680