DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdha and PDHA1

DIOPT Version :9

Sequence 1:	NP_726945.1	Gene:	Pdha / 31406	FlyBaseID:	FBgn0028325	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001166925.1	Gene:	PDHA1 / 5160	HGNCID:	8806	Length:	428	Species:	Homo sapiens

Alignment Length:	427	Identity:	228/427 - (53%)
Similarity:	291/427 - (68%)	Gaps:	14/427 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRTLSRVSELPIIVKQLQKRCHNNNNNNIIISGCRILSNNNNNSSIDIIRNGRYSSSFFGLFQN 65
            ||..:|||     :....||..|.......::|    :|....:|.:.:.:...||.|   |...
Human     4 MLAAVSRV-----LSGASQKPRHGLATLPSLVS----ISRLKQSSHLGLPKCWDYSHS---LKTR 56

  Fly    66 AAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETAAGNLY 130
            .|...:..:.|:|.:||.::.: ..||||:|||.....||::..||||..|||:||:|..|..||
Human    57 QASRVLVASRNFANDATFEIKK-CDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLY 120

  Fly   131 KEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCAR 195
            |:|||||||||..|||||.||::|.:...|::|:|||.||:|:..|:|...:||||||.:||||:
Human   121 KQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAK 185

  Fly   196 GKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAY 260
            ||||||||||.||||||||||||||||||:.|||||.|...:||.|||||||||||:|||||||.
Human   186 GKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAA 250

  Fly   261 LWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNT-H 324
            |||||.||:||||.||||||.|||:.:||||.|||.:||:.|||||:|.||.||.||..|..: .
Human   251 LWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGK 315

  Fly   325 GPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKV 389
            ||::||..||||.||||||||.||||||||||||.|.|||...|:..:...|.:.:|:|.||::|
Human   316 GPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEV 380

  Fly   390 RKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRG 426
            |||:::|..||.:|.|..:..|...:||::...::||
Human   381 RKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRG 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	209/348 (60%)
PDHA1	NP_001166925.1	PDH_E1_alph_y	96..408	CDD:274473	195/311 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143840
Domainoid	1	1.000	403	1.000	Domainoid score	I724
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1648
Isobase	1	0.950	-	0	Normalized mean entropy	S510
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D318981at33208
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		mtm8483
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	O	PTHR11516
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2211
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750