DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdha and CG7024

DIOPT Version :9

Sequence 1:	NP_726945.1	Gene:	Pdha / 31406	FlyBaseID:	FBgn0028325	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_572182.1	Gene:	CG7024 / 31407	FlyBaseID:	FBgn0029722	Length:	479	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	218/419 - (52%)
Similarity:	285/419 - (68%)	Gaps:	43/419 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RC---HNNNNNNIIISGCRILSNNNNNSSIDIIRNGRYSSSFFGLFQNAAQAGVSKTNNYATEAT 82
            ||   |:....|::   |||:              ||:..|                       .
  Fly    12 RCSGAHSILERNML---CRII--------------GRHKCS-----------------------C 36

  Fly    83 VQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETAAGNLYKEKIIRGFCHLYSGQEA 147
            :.:...||.:.|:.||..:|:|:::.||..||||..:||.||.|||.|||:.||||||||:||||
  Fly    37 LTLENTFKCYDLENGPTMDVELSREDALTMYTQMLELRRFETVAGNYYKERKIRGFCHLYNGQEA 101

  Fly   148 CAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAPNFYGGN 212
            .|||||..:|..|::|:|||.|.||||||||...::|||.||:.||:||||||||||:..|||||
  Fly   102 VAVGMKQRLRSCDSVITAYRCHAWTYLMGVSLYEIMAELFGVRTGCSRGKGGSMHMYSDKFYGGN 166

  Fly   213 GIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGM 277
            ||||||||||||:|||..|:.:.|:.:.|||||||||||:||::|||.||.||.|||||||:|||
  Fly   167 GIVGAQVPLGAGIGLAHSYRKDNGVSVVLYGDGAANQGQIFESFNMAKLWCLPCIFVCENNHYGM 231

  Fly   278 GTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNTHGPLVMETNTYRYSGHSMS 342
            ||..:|||..|::|.||..:||:||||..||||||||:||:::...|||:|:|.:||||.|||||
  Fly   232 GTHVKRASAMTEFYMRGQYIPGLWVDGNQVLAVRSATQFAVDHALKHGPIVLEMSTYRYVGHSMS 296

  Fly   343 DPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELG 407
            |||||||:|||:|..|:||||||||:...|.|.|...:|:||:|.|.||:||.....|.:|.|:.
  Fly   297 DPGTSYRSREEVQSTREKRDPITSFRSQIIALCLADEEELKALDDKTRKQVDSICKKATTDREVE 361

  Fly   408 VSHLWTDVYSNNLEPKLRGTIAYDIDHIQ 436
            :..|.||:|:.|::.|:||...:.::||:
  Fly   362 LDELHTDIYAKNVDGKIRGVSGFHLEHIK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	204/347 (59%)
CG7024	NP_572182.1	TPP_enzymes	37..381	CDD:294952	205/343 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444242
Domainoid	1	1.000	324	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_COG0462
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I637
Isobase	1	0.950	-	0	Normalized mean entropy	S510
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D30664at7147
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		mtm1206
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	P	PTHR11516
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X926
	12	11.750