Protein Alignment Pdha and Pdha2

DIOPT Version :9

• Sequence 1: NP_726945.1
• Gene: Pdha / 31406
• FlyBaseID: FBgn0028325
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_032837.1
• Gene: Pdha2 / 18598
• MGIID: 97533
• Length: 391
• Species: Mus musculus
• Alignment Length: 372
• Identity: 206/372 - (55%)
• Similarity: 265/372 - (71%)
• Gaps: 2/372 - (0%)

  Fly    56 SSSFFGLFQNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIR 120
            |..|.|:.|..|..|:..:..::.:||..:.: ..|:||:|||.|...||:.:|||||..||.||
Mouse    10 SHVFSGMVQKPALRGLLSSLKFSNDATCDIKK-CDLYRLEEGPPTSTVLTRAEALKYYRTMQVIR 73

  Fly   121 RLETAAGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAE 185
            |:|..|..|||:|.|||||||..|||||.||::|.:...|::|::||.||:.|..|:|...:|||
Mouse    74 RMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPTDHVITSYRAHGFCYTRGLSVKSILAE 138

  Fly   186 LTGVQGGCARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQG 250
            |||.:||||:|||||||||..|||||||||||||||||||..||||..||.:|||||||||||||
Mouse   139 LTGRKGGCAKGKGGSMHMYGKNFYGGNGIVGAQVPLGAGVAFACKYLKNGQVCLALYGDGAANQG 203

  Fly   251 QVFEAYNMAYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATE 315
            ||||||||:.|||||.:|:||||.||||||:||::.:|||:.:|..:||:.|:|||:|.||.||:
Mouse   204 QVFEAYNMSALWKLPCVFICENNLYGMGTSNERSAASTDYHKKGFIIPGLRVNGMDILCVREATK 268

  Fly   316 FAINYVNT-HGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITT 379
            ||.::..: .||:|||..||||.||||||||.|||:|||:..||.|.|||...:|..|...|...
Mouse   269 FAADHCRSGKGPIVMELQTYRYHGHSMSDPGISYRSREEVHNVRSKSDPIMLLRERIISNNLSNI 333

  Fly   380 DEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRG 426
            :|:|.||..|:|||::|..||.:|.|..|..:...:|..:...::||
Mouse   334 EELKEIDADVKKEVEDAAQFATTDPEPAVEDIANYLYHQDPPFEVRG 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	198/348 (57%)
Pdha2	NP_032837.1	PDH_E1_alph_y	59..371	CDD:274473	186/311 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834077
Domainoid	1	1.000	403	1.000	Domainoid score	I726
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1627
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54057
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		otm43434
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	O	PTHR11516
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2211
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790