Protein Alignment Pdha and Pdha1

DIOPT Version :10

• Sequence 1: NP_726945.1
• Gene: Pdha / 31406
• FlyBaseID: FBgn0028325
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_032836.1
• Gene: Pdha1 / 18597
• MGIID: 97532
• Length: 390
• Species: Mus musculus
• Alignment Length: 367
• Identity: 214/367 - (58%)
• Similarity: 269/367 - (73%)
• Gaps: 2/367 - (0%)

  Fly    61 GLFQNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETA 125
            |..|..|...:..:.|:|.:||.::.: ..||||:|||.....||::..||||..|||:||:|..
Mouse    14 GSAQKPASRVLVASRNFANDATFEIKK-CDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELK 77

  Fly   126 AGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQ 190
            |..|||:|||||||||..|||||.||::|.:...|::|:|||.||:|:..|:....:||||||.:
Mouse    78 ADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLPVRAILAELTGRR 142

  Fly   191 GGCARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEA 255
            ||||:||||||||||.||||||||||||||||||:.|||||.|...:||.|||||||||||:|||
Mouse   143 GGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEA 207

  Fly   256 YNMAYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINY 320
            ||||.|||||.||:||||.||||||.|||:.:||||.|||.:||:.|||||:|.||.||:||..|
Mouse   208 YNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAY 272

  Fly   321 VNT-HGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKA 384
            ..: .||::||..||||.||||||||.||||||||||||.|.|||...|:..:...|.:.:|:|.
Mouse   273 CRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE 337

  Fly   385 IDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRG 426
            ||::||||:::|..||.:|.|..:..|...:||::...::||
Mouse   338 IDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRG 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:470272	208/348 (60%)
Pdha1	NP_032836.1	PDH_E1_alph_y	58..370	CDD:274473	194/311 (62%)