Protein Alignment Pdha and Pdha2

DIOPT Version :9

• Sequence 1: NP_726945.1
• Gene: Pdha / 31406
• FlyBaseID: FBgn0028325
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_446446.1
• Gene: Pdha2 / 117098
• RGDID: 620095
• Length: 391
• Species: Rattus norvegicus
• Alignment Length: 372
• Identity: 210/372 - (56%)
• Similarity: 268/372 - (72%)
• Gaps: 2/372 - (0%)

  Fly    56 SSSFFGLFQNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIR 120
            |..|.|:.|..|..|:..:..::.:||..:.: ..|:.|::||.|...||:::|||||..||.||
  Rat    10 SQVFSGMVQKPALRGLLSSLKFSNDATCDIKK-CDLYLLEQGPPTSTVLTREEALKYYRNMQVIR 73

  Fly   121 RLETAAGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAE 185
            |:|..|..|||:|.|||||||..|||||.||::|.:...|:||::||.||..|..|:|...:|||
  Rat    74 RMELKADQLYKQKFIRGFCHLCDGQEACNVGLEAGINPTDHIITSYRAHGLCYTRGLSVKSILAE 138

  Fly   186 LTGVQGGCARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQG 250
            |||.:||||:||||||||||.|||||||||||||||||||.|||||..||.:|||||||||||||
  Rat   139 LTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGVALACKYLKNGQICLALYGDGAANQG 203

  Fly   251 QVFEAYNMAYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATE 315
            ||||||||:.|||||.:|:||||.|||||:.||::.:|||:.:|..:||:.|:|||:|:||.||:
  Rat   204 QVFEAYNMSALWKLPCVFICENNRYGMGTAIERSAASTDYHKKGFVIPGLRVNGMDILSVREATK 268

  Fly   316 FAINYVNT-HGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITT 379
            ||.::..: .||:|||..||||.||||||||.|||||||:|.||.|.|||...:|..|...|.:.
  Rat   269 FAADHCRSGKGPIVMELQTYRYHGHSMSDPGISYRTREEVQNVRSKSDPIMLLRERMISNNLSSV 333

  Fly   380 DEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRG 426
            :|:|.||..|:|||:||..||.:|.|..:..|...:|..|...::||
  Rat   334 EELKEIDADVKKEVEEAAQFATTDPEPPLEDLANYLYHQNPPFEVRG 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	202/348 (58%)
Pdha2	NP_446446.1	PDH_E1_alph_y	59..371	CDD:274473	191/311 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337617
Domainoid	1	1.000	401	1.000	Domainoid score	I712
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1593
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D318981at33208
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		otm45497
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	O	PTHR11516
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910