DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Torsin and tor1

DIOPT Version :9

Sequence 1:	NP_001284866.1	Gene:	Torsin / 31399	FlyBaseID:	FBgn0025615	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001186944.1	Gene:	tor1 / 565062	ZFINID:	ZDB-GENE-080917-50	Length:	336	Species:	Danio rerio

Alignment Length:	319	Identity:	103/319 - (32%)
Similarity:	180/319 - (56%)	Gaps:	14/319 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SVDPLTIG-AVGAVA-----LGAYFKEHTYCRFAECCDDRNIPARIDELERSLERTLIGQHIVRQ 82
            :::|::.. |||..|     |..|  ::.:..|.|||....|......|:..|:..|.|||:..|
Zfish    21 AIEPISTSIAVGMAAALTGFLAGY--QNMFYYFNECCRPEWISYNKTGLKYDLDTKLYGQHVAGQ 83

  Fly    83 HIVPALKAHIASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQADFPKE 147
            .|:.|:...: :..|.:||||:|.||..|||||||::.:|:.:|:||..|::|..:...|.||.|
Zfish    84 VILKAVTGFM-NNKKPKKPLVLSLHGWTGTGKNFVSQLLAENIYVKGMESSFVHLFTATAHFPHE 147

  Fly   148 SEVSNYRVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAFVDGTDNTKAIFIFL 212
            ..:..|:.::.:.:|..:..||||:|||||:|||..|:.|.:...:|:...::|....:||||||
Zfish   148 IHIDTYKTQLQDWIRGNVSICPRSMFIFDEMDKMHPGLIDSIKPYLDFYDNLNGVSYREAIFIFL 212

  Fly   213 SNTAGSHIASHLGSVMKNGRLREDTRLSDFEPLLRKAAY-NMDGGMKKTTMIESHVIDHFIPFLP 276
            ||..|.:|........|:|:.||:.:|...|..|..:.: |.:.|...|::|:.:::|.|:||||
Zfish   213 SNAGGENIVQVALDFWKDGKEREEIQLKHLETALSLSVFNNKNSGFWHTSLIDKNLVDFFVPFLP 277

  Fly   277 MEKAHVIKCLEAELLRWRRDPKQANNQKIIEDIINSSISYDRTHSLFAISGCKTLEKKV 335
            :|..|:|:|..||::.....|    :::::|.:.:....:.:...:|::.|||.:..::
Zfish   278 LEYKHIIQCGLAEMIAKGHSP----DKEVVEKMAHDLNYFPKEERVFSMQGCKVIPSRL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Torsin	NP_001284866.1	P-loop_NTPase	48..175	CDD:304359	46/126 (37%)
Torsin	NP_001284866.1	AAA	100..224	CDD:214640	52/123 (42%)
tor1	NP_001186944.1	P-loop_NTPase	50..175	CDD:304359	46/125 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580531
Domainoid	1	1.000	105	1.000	Domainoid score	I6569
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3879
OMA	1	1.010	-	-		QHG49139
OrthoDB	1	1.010	-	-		D1453168at2759
OrthoFinder	1	1.000	-	-		FOG0001199
OrthoInspector	1	1.000	-	-		otm24793
orthoMCL	1	0.900	-	-		OOG6_104781
Panther	1	1.100	-	-	LDO	PTHR10760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3548
SonicParanoid	1	1.000	-	-		X455
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900