DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Torsin and TOR4A

DIOPT Version :9

Sequence 1:	NP_001284866.1	Gene:	Torsin / 31399	FlyBaseID:	FBgn0025615	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_060193.2	Gene:	TOR4A / 54863	HGNCID:	25981	Length:	423	Species:	Homo sapiens

Alignment Length:	339	Identity:	77/339 - (22%)
Similarity:	127/339 - (37%)	Gaps:	86/339 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LTIGAVGAVALGAYFKEHTYCRFAECCDDRNIPARIDELERSLERTLIGQHIVRQHIVPALKAHI 92
            |.:..||...|.|          .|..||......:|.||::|:|.:.||......||..::.::
Human   125 LLVAIVGFQVLNA----------IENLDDNAQRYDLDGLEKALQRAVFGQPAAVSRIVALMRDYL 179

  Fly    93 ASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQADFPKESEVSNYRVKI 157
            |:...|| ||:::.||..|.||:.|...:|.........|..|.:|..:...|:.....:.|.::
Human   180 ATHVHSR-PLLLALHGPSGVGKSHVGRLLARHFRSVLEDSALVLQYHARHHCPEARAAQDCREEL 243

  Fly   158 NNAVRDTLRSCPRS----LFIFDEVDKMPSGVFDQLTSLVD-------YNAFVDGTDNTKAIFIF 211
            ...|.|.:......    |.:.|:|:.||..:.|:|...:.       :|          ||::.
Human   244 ARRVADVVARAEAEEKTPLLVLDDVELMPRPLLDELHGFLQPQRSHHFHN----------AIYVL 298

  Fly   212 LSNTAGSHIASHLGSVMKN-------------------GRLREDTR------LSDFEPLLRKAAY 251
            ||...|:.:...   |::|                   .:..||.|      ||...||.:.||
Human   299 LSGAGGAEVTRF---VLQNASRALPLRPDGFRSAEAAAAQAEEDLRASLLAVLSREHPLWQAAA- 359

  Fly   252 NMDGGMKKTTMIESHVIDHFIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQKIIEDIINSSISY 316
                               .:|||.::|..|:.|...|:......|.||..:.:.     :.:|:
Human   360 -------------------IVPFLLLDKRDVVSCFRDEMAGEGFFPDQARAENLA-----AQLSF 400

  Fly   317 DRTHSL-FAISGCK 329
            .|.... ||::|||
Human   401 YRVAGREFAVTGCK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Torsin	NP_001284866.1	P-loop_NTPase	48..175	CDD:304359	32/130 (25%)
Torsin	NP_001284866.1	AAA	100..224	CDD:214640	29/134 (22%)
TOR4A	NP_060193.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..68
		P-loop_NTPase	149..253	CDD:304359	28/104 (27%)
		AAA	186..>290	CDD:214640	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147054
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2170
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.800