Protein Alignment Torsin and Tor1a

DIOPT Version :9

• Sequence 1: NP_001284866.1
• Gene: Torsin / 31399
• FlyBaseID: FBgn0025615
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_659133.1
• Gene: Tor1a / 30931
• MGIID: 1353568
• Length: 333
• Species: Mus musculus
• Alignment Length: 331
• Identity: 113/331 - (34%)
• Similarity: 187/331 - (56%)
• Gaps: 18/331 - (5%)

  Fly    12 LSVLVILPLPLQSVDPLTIGAVGAVALGAYFK-EHTYCRFAECCDDRNIPARIDELERSLERTLI 75
            |::|::.|..:::|:|:::....|..|..|.. ...||.|||||......:| :.|::.|:..|.
Mouse     8 LALLLLAPCVVRAVEPISLSLALAGVLTTYISYPRLYCLFAECCGQMRSLSR-EALQKDLDNKLF 71

  Fly    76 GQHIVRQHIVPALKAHIASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLG 140
            |||:.::.|:.|:...: |..|.:|||.:|.||..||||||.::.||:.:|..|..|:||..::.
Mouse    72 GQHLAKKVILNAVSGFL-SNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVA 135

  Fly   141 QADFPKESEVSNYRVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAFVDGTDNT 205
            ...||..|.::.|:.::...:|..:.:|.||:|||||:|||.:|:.|.:...:||...||.....
Mouse   136 TLHFPHASNITQYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQ 200

  Fly   206 KAIFIFLSNTAGSHIASHLGSVMKNGRLREDTRLSDFEPLLRKAAY-NMDGGMKKTTMIESHVID 269
            |||||||||.....|........|:|:.||:.:|.|.||.|..:.: |.:.|...:::|:.::||
Mouse   201 KAIFIFLSNAGAERITDVALDFWKSGKQREEIKLRDMEPALAVSVFNNKNSGFWHSSLIDRNLID 265

  Fly   270 HFIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQKIIEDIINSSISYDRT-----HSLFAISGCK 329
            :|:||||:|..|:..|:..|:        |:...::.|||| |.::.:.|     ..:|:..|||
Mouse   266 YFVPFLPLEYKHLKMCIRVEM--------QSRGYEVDEDII-SKVAEEMTFFPKEEKVFSDKGCK 321

  Fly   330 TLEKKV 335
            |:..|:
Mouse   322 TVFTKL 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Torsin	NP_001284866.1	P-loop_NTPase	48..175	CDD:304359	45/126 (36%)
		AAA	100..224	CDD:214640	51/123 (41%)
Tor1a	NP_659133.1	Torsin	45..170	CDD:148114	45/126 (36%)
		Interaction with SNAPIN. /evidence=ECO:0000250	92..252		62/159 (39%)
		Interaction with KLC1. /evidence=ECO:0000250	252..333		26/85 (31%)
		Interaction with SYNE3. /evidence=ECO:0000250	313..333		6/15 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836993
Domainoid	1	1.000	102	1.000	Domainoid score	I6803
eggNOG	1	0.900	-	-		E1_KOG2170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37263
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3732
Isobase	1	0.950	-	0	Normalized mean entropy	S4332
OMA	1	1.010	-	-		QHG49139
OrthoDB	1	1.010	-	-		D1453168at2759
OrthoFinder	1	1.000	-	-		FOG0001199
OrthoInspector	1	1.000	-	-		otm42470
orthoMCL	1	0.900	-	-		OOG6_104781
Panther	1	1.100	-	-	LDO	PTHR10760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3548
SonicParanoid	1	1.000	-	-		X455
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750