DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Torsin and TOR1A

DIOPT Version :9

Sequence 1:	NP_001284866.1	Gene:	Torsin / 31399	FlyBaseID:	FBgn0025615	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_000104.1	Gene:	TOR1A / 1861	HGNCID:	3098	Length:	332	Species:	Homo sapiens

Alignment Length:	330	Identity:	115/330 - (34%)
Similarity:	189/330 - (57%)	Gaps:	17/330 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSVLVILPLPLQSVDPLTIGAVGAVALGAYFKEHTYCRFAECCDDRNIPARIDELERSLERTLIG 76
            |.:|::.|..:|:|:|:::|...|..|..|.....||.|||||..:...:| :.|::.|:..|.|
Human     8 LGLLLLAPSVVQAVEPISLGLALAGVLTGYIYPRLYCLFAECCGQKRSLSR-EALQKDLDDNLFG 71

  Fly    77 QHIVRQHIVPALKAHIASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQ 141
            ||:.::.|:.|:...| :..|.:|||.:|.||..|||||||::.||:.:|..|..|:||..::..
Human    72 QHLAKKIILNAVFGFI-NNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIYEGGLNSDYVHLFVAT 135

  Fly   142 ADFPKESEVSNYRVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAFVDGTDNTK 206
            ..||..|.::.|:.::...:|..:.:|.||:|||||:|||.:|:.|.:...:||...|||....|
Human   136 LHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDLVDGVSYQK 200

  Fly   207 AIFIFLSNTAGSHIASHLGSVMKNGRLREDTRLSDFEPLLRKAAY-NMDGGMKKTTMIESHVIDH 270
            |:||||||.....|........::|:.|||.:|.|.|..|..:.: |.:.|...:::|:.::||:
Human   201 AMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHALSVSVFNNKNSGFWHSSLIDRNLIDY 265

  Fly   271 FIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQKIIEDIINSSISYDRT-----HSLFAISGCKT 330
            |:||||:|..|:..|:..|:        |:...:|.|||: |.::.:.|     ..:|:..||||
Human   266 FVPFLPLEYKHLKMCIRVEM--------QSRGYEIDEDIV-SRVAEEMTFFPKEERVFSDKGCKT 321

  Fly   331 LEKKV 335
            :..|:
Human   322 VFTKL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Torsin	NP_001284866.1	P-loop_NTPase	48..175	CDD:304359	46/126 (37%)
Torsin	NP_001284866.1	AAA	100..224	CDD:214640	52/123 (42%)
TOR1A	NP_000104.1	Torsin	44..169	CDD:148114	46/126 (37%)
		Interaction with SNAPIN	91..251		62/159 (39%)
		Interaction with KLC1. /evidence=ECO:0000269\|PubMed:14970196	251..332		26/85 (31%)
		Interaction with SYNE3. /evidence=ECO:0000269\|PubMed:18827015	312..332		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147050
Domainoid	1	1.000	106	1.000	Domainoid score	I6568
eggNOG	1	0.900	-	-		E1_KOG2170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37263
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3713
Isobase	1	0.950	-	0	Normalized mean entropy	S4332
OMA	1	1.010	-	-		QHG49139
OrthoDB	1	1.010	-	-		D1453168at2759
OrthoFinder	1	1.000	-	-		FOG0001199
OrthoInspector	1	1.000	-	-		otm40398
orthoMCL	1	0.900	-	-		OOG6_104781
Panther	1	1.100	-	-	LDO	PTHR10760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3548
SonicParanoid	1	1.000	-	-		X455
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750