DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH4C and HAND2

DIOPT Version :9

Sequence 1:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_068808.1	Gene:	HAND2 / 9464	HGNCID:	4808	Length:	217	Species:	Homo sapiens

Alignment Length:	161	Identity:	46/161 - (28%)
Similarity:	64/161 - (39%)	Gaps:	53/161 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MIGPNNPHLVNEDYA---------ASTTLDIDKRFQARMACETAAQPAPPPP----PTPAPRRRT 80
            :||  :|.:...||:         ||....:|.....      ...|...||    |.|..||.|
Human    47 LIG--HPEMSPPDYSMALSYSPEYASGAAGLDHSHYG------GVPPGAGPPGLGGPRPVKRRGT 103

  Fly    81 TPIAHLDPSELVGLSREERRRRRRATLKYRTAHATRERIRVEAFNVSFAELRKLLPTLPPDKKLS 145
            .             :|:|||                   |.::.|.:|||||:.:|.:|.|.|||
Human   104 A-------------NRKERR-------------------RTQSINSAFAELRECIPNVPADTKLS 136

  Fly   146 KIEILKLAICYIAYLNHVLETPXDSAGASSF 176
            ||:.|:||..|||||..:|... .:..|.:|
Human   137 KIKTLRLATSYIAYLMDLLAKDDQNGEAEAF 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	23/56 (41%)
HAND2	NP_068808.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..116		14/77 (18%)
HAND2	NP_068808.1	bHLH_TS_HAND2	100..161	CDD:381477	31/92 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810