DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH4C and HAND1

DIOPT Version :9

Sequence 1:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_004812.1	Gene:	HAND1 / 9421	HGNCID:	4807	Length:	215	Species:	Homo sapiens

Alignment Length:	129	Identity:	46/129 - (35%)
Similarity:	57/129 - (44%)	Gaps:	14/129 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FQARMACETAAQP----APPPPPTPAPRRRTTPIAH--LDPSELVGLSREERRRRRRATLKYRTA 112
            ||:.:.....|.|    ..|||...|......|.|.  ..|..|..|.....||:.....|
Human    42 FQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKK---- 102

  Fly   113 HATRERIRVEAFNVSFAELRKLLPTLPPDKKLSKIEILKLAICYIAYLNHVLETPXDSAGASSF 176
                ||.|.|:.|.:|||||:.:|.:|.|.|||||:.|:||..|||||..||... .|....:|
Human   103 ----ERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAF 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	28/56 (50%)
HAND1	NP_004812.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..109		16/63 (25%)
		bHLH_TS_HAND1	94..153	CDD:381522	31/66 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..198
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810