DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH4C and TAL1

DIOPT Version :9

Sequence 1:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_001274276.1	Gene:	TAL1 / 6886	HGNCID:	11556	Length:	331	Species:	Homo sapiens

Alignment Length:	152	Identity:	48/152 - (31%)
Similarity:	63/152 - (41%)	Gaps:	48/152 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ETAAQPAPPPPPTP-------------------------APRRR-----TTPIAHL------DPS 89
            |....|.|.|.|.|                         ||.|.     :.|:|.|      :|.
Human    92 ELCRPPGPAPAPAPASVTAELPGDGRMVQLSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPD 156

  Fly    90 ELVGLSREERRRRRRATLKY------------RTAHATRERIRVEAFNVSFAELRKLLPTLPPDK 142
            .....:...|.:||.:..:.            |....:|||.|.:..|.:|||||||:||.||||
Human   157 AFPMFTTNNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDK 221

  Fly   143 KLSKIEILKLAICYIAYLNHVL 164
            ||||.|||:||:.||.:|..:|
Human   222 KLSKNEILRLAMKYINFLAKLL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	32/69 (46%)
TAL1	NP_001274276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..86
		HLH	193..243	CDD:197674	30/49 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5161
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860