DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH4C and hand2

DIOPT Version :9

Sequence 1:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_571701.3	Gene:	hand2 / 58150	ZFINID:	ZDB-GENE-000511-1	Length:	205	Species:	Danio rerio

Alignment Length:	164	Identity:	47/164 - (28%)
Similarity:	74/164 - (45%)	Gaps:	27/164 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MIG--PNNPHLVNEDYAASTTLDIDKRFQARMACE---------TAAQPAPPPP-----PTPAPR 77
            ::|  |::|.:.::.|:          |.|...|.         ..:.|...||     |:.:|
Zfish     3 LVGGFPHHPVMHHDGYS----------FAAASRCHEEPPYFHGWLISHPEMSPPDYTMAPSYSP- 56

  Fly    78 RRTTPIAHLDPSELVGLSREERRRRRRATLKYRTAHATRERIRVEAFNVSFAELRKLLPTLPPDK 142
            ..:|....||.|...|:...........|:|.|.....:||.|.::.|.:|||||:.:|.:|.|.
Zfish    57 EYSTGAPGLDHSHYGGVPGAGAVGMGPRTVKRRPTANRKERRRTQSINSAFAELRECIPNVPADT 121

  Fly   143 KLSKIEILKLAICYIAYLNHVLETPXDSAGASSF 176
            |||||:.|:||..|||||..:|:....:....:|
Zfish   122 KLSKIKTLRLATSYIAYLMDILDKDEQNGETEAF 155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	27/56 (48%)
hand2	NP_571701.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..103		6/26 (23%)
		HLH	88..139	CDD:278439	24/50 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..194
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810