DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH4C and Ascl3

DIOPT Version :9

Sequence 1:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_064435.1	Gene:	Ascl3 / 56787	MGIID:	1928820	Length:	174	Species:	Mus musculus

Alignment Length:	191	Identity:	52/191 - (27%)
Similarity:	72/191 - (37%)	Gaps:	57/191 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPQSIS---------LSR-YYLVDDDEMIG----PNNPHLVNEDYA--------ASTTLDIDKRF 54
            ||..:|         ||| :||   |.|:.    |..|  |...|.        :|.||.::
Mouse     9 PPDRLSVFAESAHLPLSRPFYL---DPMVTVHLCPETP--VPASYTDELPLLPFSSDTLIMN--- 65

  Fly    55 QARMACETAAQPAPPPPPTPAPRRRTTPIAHLDPSELVGLSREERRRRRRATLKYRTAHATRERI 119
                   ....|.|.|.|.|....|.....: .|:.:        |:|..           |||.
Mouse    66 -------NYGDPYPFPFPMPYTNYRRCDYTY-GPAFI--------RKRNE-----------RERQ 103

  Fly   120 RVEAFNVSFAELRKLLPTLPPDKKLSKIEILKLAICYIAYLNHVLETPXDSAGASSFATSC 180
            ||:..|..:|.||:.||....:|:|||:|.|:.||.||:||..:|... .....:....||
Mouse   104 RVKCVNEGYARLRRHLPEDYLEKRLSKVETLRAAIKYISYLQSLLYPDESETKKNPRTASC 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	23/56 (41%)
Ascl3	NP_064435.1	HLH	95..145	CDD:278439	24/60 (40%)
Ascl3	NP_064435.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..174		2/12 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810