DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH4C and FERD3L

DIOPT Version :9

Sequence 1:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_690862.1	Gene:	FERD3L / 222894	HGNCID:	16660	Length:	166	Species:	Homo sapiens

Alignment Length:	182	Identity:	51/182 - (28%)
Similarity:	72/182 - (39%)	Gaps:	46/182 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MAAGPPQSISLSRYYLVDDDEMIGPNNPHLVNEDYAASTTLDIDKRFQARMACETAAQPAPPPPP 72
            |||.|...:..:....|.|..:..|..|.|.  |:|...:|.                     .|
Human     1 MAAYPESCVDTTVLDFVADLSLASPRRPLLC--DFAPGVSLG---------------------DP 42

  Fly    73 TPAPR----RRTTPIAHLDPSELV-------GLSREER------------RRRRRATLKYRTAHA 114
            ..|.|    ||.......||.|..       |...||.            :|:|..|...|.|..
Human    43 ALALREGRPRRMARFEEGDPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVITYAQRQAAN 107

  Fly   115 TRERIRVEAFNVSFAELRKLLPTLPPDKKLSKIEILKLAICYIAYLNHVLET 166
            .|||.|:...|.:|.:||:.:||...:|:||:||.|:|||.||:::..:||:
Human   108 IRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLES 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	23/56 (41%)
FERD3L	NP_690862.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..88		6/30 (20%)
FERD3L	NP_690862.1	bHLH_TS_FERD3L_NATO3	94..157	CDD:381421	26/62 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810