DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH4C and MESP2

DIOPT Version :9

Sequence 1:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_001035047.1	Gene:	MESP2 / 145873	HGNCID:	29659	Length:	397	Species:	Homo sapiens

Alignment Length:	127	Identity:	38/127 - (29%)
Similarity:	54/127 - (42%)	Gaps:	29/127 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CETAAQPAPPPPPTPAPR----RRTTPIAHLDPSELVGLSREERRRRRRATLKYRTAHATRERIR 120
            |:.|.....|.||:.:.|    ..|||                ||.|.......|.:.:.||::|
Human    45 CDGARGLPQPQPPSCSSRAAEAAATTP----------------RRARTGPAGGQRQSASEREKLR 93

  Fly   121 VEAFNVSFAELRKLLP--TLPPDKKLSKIEILKLAICYIAYLNHVLETPXDSAGASSFATSC 180
            :.....:..|||:.||  ..|..:.|:|||.|:|||.||.:|:.||       |.|..:..|
Human    94 MRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVL-------GLSEESLQC 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	22/58 (38%)
MESP2	NP_001035047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..92		15/62 (24%)
		HLH	82..135	CDD:278439	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..208
		13 X 2 AA tandem repeats of G-Q	179..204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..295
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810