Protein Alignment Alms1b and alms1

DIOPT Version :10

• Sequence 1: NP_001259240.1
• Gene: Alms1b / 31392
• FlyBaseID: FBgn0025387
• Length: 987
• Species: Drosophila melanogaster
• Sequence 2: NP_001429403.1
• Gene: alms1 / 561882
• ZFINID: ZDB-GENE-030131-4837
• Length: 2124
• Species: Danio rerio
• Alignment Length: 1206
• Identity: 215/1206 - (17%)
• Similarity: 401/1206 - (33%)
• Gaps: 417/1206 - (34%)

  Fly    63 QPPGCASMEHEARPESGHRRRTKSSDHRSPDERGEAKEQLRELSVSPPPSKHNISQ--------- 118
            :|.||::    |.|:.|....|.|.          .:..|..::||.|.::.:.|:
Zfish  1013 EPEGCSA----ADPDKGKPTTTTSG----------TQINLPSIAVSVPQNEEDTSEDAPIGSSEN 1063

  Fly   119 ---FTSPKSEVTQTKPNEYTIIPIV--LASSPSFRSVAVTQTMSQSAGDIR-----------RPI 167
               ..|.::|......:|.::...|  |..|.|..|:..::..:....|.|           |..
Zfish  1064 SLSHVSAEAESLSDSSSESSLAARVAKLLQSESPVSMVTSRPSTADPEDSRAREWILMKVSGRRC 1128

  Fly   168 KSPQMQNKKTQTLESVHK----SHKHTKKCQCKSRRQDSKVSSCQTDIHHPEREQQEIQPLMRDQ 228
            :|.::..:..:.:|.:.:    :.|:||      ...||: .|.|:.|....::.:....|...:
Zfish  1129 ESLELNTEDRKRIEEIKRELLLNTKYTK------WSSDSE-GSAQSSIGLESQQTKGYVGLRNME 1186

  Fly   229 RKAKQRHEKDHQLEREQQGIQQLTRDQRKATKREKVREQERQYTAAQFEKIRGNRRHVSKENQQP 293
            .:...      ||::.........:|.........:||   .::...|..|..:   .::....|
Zfish  1187 NRLSD------QLQKAPSNPLSTVQDLEAKVHEIALRE---GFSTKPFTSITIS---TTRRTPSP 1239

  Fly   294 ENPVVNPSTGVTASSSTTSLDVGSGSR-PRGVLDIGIELVC--SLVKSRSLSQGQKKKLVRDIAR 355
            ::|..:|.||....:     :|||.:. |.|..|...|...  ..:..:..::.:::..:.|.|:
Zfish  1240 QSPPHSPVTGTLKIT-----NVGSANETPAGTKDSDREKETEGQHIDEKKTTEDKQENTITDKAQ 1299

  Fly   356 RISCLE--LTESSTSSRS--------LSSSSKEQLK------------------VPTGS------ 386
            |:|.::  :|.|:.:::|        ||...|.|::                  ||:.:
Zfish  1300 RMSHIDYNVTSSTFNNKSHLSHIHVTLSPKPKNQIRFEKSTQNISQDVALQRPIVPSVADPQLEP 1364

  Fly   387 ---------------LQQVAATNTNQSNAR-------SSSKAERIAPPVPAPRKRAAIGSSSPLP 429
                           .::|...||.:.:||       ||:.:.|:.........:.|.|::: :|
Zfish  1365 MHRISTLNHVSSYEYRERVQGQNTGRVSARFPARHTQSSAPSNRLDMKSRTLSGQTAYGTAA-VP 1428

  Fly   430 ESVSYSGSTSGSGEVI----TQKTNIPNRNASTDADIEPLDLQDWLNPMTLSEIEFEERLKGGTD 490
            ..:.|  ...||.|:.    ......|.|:.:|.....| |..|.:.|      .|.:.:.|..:
Zfish  1429 TLLPY--KPHGSSELFYMPQVDPELSPGRSDTTVESSHP-DSDDAVPP------HFNKDILGSRE 1484

  Fly   491 SE-------RRRQLHWVKTEINRMQEFKNLLESISLPSKSQKKANTESATAAQI-PSSMRCMGDQ 547
            .|       .:..::..:|.:|:       :.|...|.||   |:|..:||.:: ..:|..:|..
Zfish  1485 QEDNTITPKHKEGIYSKRTNMNK-------VSSGDCPPKS---ASTFVSTAPEVSKKNMETVGID 1539

  Fly   548 KERPDKE-YLLRQEMSAEAESKEMENSETTTTPPPPVRIESVGVNVTNSDPSTLPAPPPTQPPPP 611
            .|..||| :.:...|.|: .|.:..:...:||..|.:                     |.:|...
Zfish  1540 AEYNDKEDHFVPLNMEAD-NSMDHVHFHNSTTQEPKI---------------------PREPHYS 1582

  Fly   612 PPHLNQRNLQNRKKMATPLLVSGSSTSGGGRSESVCSFVQQRQRQFCEHYENEQLE-----EFVL 671
            ....|:|..:..||        |...:....|..:.|.:.|..|:|.|.:..|:..     |..|
Zfish  1583 SSQPNRRPYRGNKK--------GKDRTPHDVSLEITSSLDQLWRRFNEKWSTEESRSINDGETSL 1639

  Fly   672 LQKQKLYQLRKQLNQ--QKDILIQRQQHCGQRTYVHQQHCPRRQQEAQDQHD------------- 721
            |  .:|.:|.:.::.  ..|..:|:....|...|...     |.||.::|.:
Zfish  1640 L--DRLERLSRLIHNTTPTDHSVQQSSDSGNGEYDRM-----RNQEEEEQRERVQLKAPPKHAWV 1697

  Fly   722 -------------EREQYMQM----------QYAQAAGAYASGAVGNEA------IYHQV----V 753
                         ||::.::.          :..:|.||:.....|.::      :|:.:    .
Zfish  1698 QDEGQGKVHLCPAERDESVETSSSVSTVDTERLQRAFGAHRVAREGMKSDGSLLRLYNSINAKKT 1762

  Fly   754 NPQGVASYVQATMVSTETQNEATATGGAGGSSITRCETTTR-------------------QYDDV 799
            :.:..::...|..|:|:..:::|.:.|:..||.|....:.|                   |..|:
Zfish  1763 SRRKPSTKDAAVSVTTDNTDDSTVSAGSLSSSSTSFHHSQRGVYSLKTKKSKVKLVSKSVQAGDL 1827

  Fly   800 ----------------------ACQRVRRGHK--------------------ETRMNAERMQRQV 822
                                  |.:.|...:|                    :|.:..:...:.|
Zfish  1828 EIVINGTRKHTRDVGTVFPSPGAFKNVSSSNKFGSGLQNGIPIPTASTAKPIQTALKRDSSNKSV 1892

  Fly   823 R---PRAISYVIQ--------------------------FTPTG--------------------- 837
            |   |..:|:.:.                          |.|..
Zfish  1893 RTRYPHGVSWFVSADELKFDGRKENQPQNESEPSISQAWFEPYSRTRPWRESSREPLRERQNQQE 1957

  Fly   838 -----------SSEVIEKPP-----SLQDQLQLARPEFCANAKQRKAIL------NEMQMIRNAR 880
                       .:::.:|..     |||:.|:|.||||.:.:::|...|      ..:|.|.|..
Zfish  1958 QERQTETRTAMETDISDKTSALVRLSLQEALELHRPEFVSRSRERMKRLGLLVEERRLQAIFNRE 2022

  Fly   881 RQELDNVLSQSTSMEALNRHLEQLPPAANTRVKLFTTREM---------KAITSKRC-------- 928
            |:||.|..:.|..:.|          |...|.::...:||         |...|:|.
Zfish  2023 REELFNFPAPSRPLRA----------APVPRKRVVPRKEMVQRSRDWVGKKSHSQRIDRTDRLRR 2077

  Fly   929 --KNLPEVLAAQSRQEEEQRR---RSNRLMRDAFNK 959
              ..||||   |.|:|||:||   ||.||....|||
Zfish  2078 KYAKLPEV---QKRREEEKRRAEYRSYRLTAQLFNK 2110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alms1b	NP_001259240.1	ALMS_motif	847..959	CDD:464634	43/139 (31%)
alms1	NP_001429403.1	None