DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment peb and salm

DIOPT Version :9

Sequence 1:	NP_001014722.1	Gene:	peb / 31391	FlyBaseID:	FBgn0003053	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster

Alignment Length:	1715	Identity:	312/1715 - (18%)
Similarity:	475/1715 - (27%)	Gaps:	719/1715 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QQHNNSTVESEMERQRRD---------STTSESSLEHLDLGRTPKK------------------- 42
            :.:||....::...:.|:         |..:|:|.|.....|||:|
  Fly   121 EDNNNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSS 185

  Fly    43 --------LGGNSGSTQTTSTPHEL---------ATVTS--------SRKRKIRHLQ--LNHHQQ 80
                    |.|.:|:..|......:         .|:.:        :..:::..||  |.:.||
  Fly   186 AVPSTEVTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQ 250

  Fly    81 QQHHQ-------QSDLLSDEDVAEAEAEEDEDEEDG--------DQVAALGSRNLGRHKQRRSGG 130
            ||..|       ||.|..::...|.:.|||.|:|..        ::...:....|.:..:.|...
  Fly   251 QQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQKAEARMAE 315

  Fly   131 ATTQ-----ASIVMDYSSGDASSLRKKFRLNRSAASLSESGFVDASSTTGHSGYLGNSSSA-TNT 189
            |..:     |.:.:..|||..:...|:.|.:            |..|.......|.|:..| |..
  Fly   316 AKARQHLINAGVPLRESSGSPAESLKRRREH------------DHESQPNRRPSLDNTHKADTAQ 368

  Fly   190 TATSGIGASAVAPSPVGGAAINA--------------------ASSSSGSSSGGSGGSSPQGQCL 234
            .|.:.:......|.|.|....::                    |.....|:|.|...:|......
  Fly   369 DALAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLLQKRAQEVLDSASQGILANSMADDFA 433

  Fly   235 SSGESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDR 299
            ...:||.|.|..                ..|..|              .||.|.||..|.|:|..
  Fly   434 FGEKSGEGKGRN----------------EPFFKH--------------RCRYCGKVFGSDSALQI 468

  Fly   300 HVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQ---HQVAQSQSQSQQQQSLQQQQQSQQQRR 361
            |:..|||||||.|..|...|||.||:..|.:.|.|   |....:....:...........|....
  Fly   469 HIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPT 533

  Fly   362 QQQ-QHQPS------------------QQQQNPAQQQLMGNTLSARAESYESDASCSTDVSSGHS 407
            ... .|.|:                  |....|..:.|  .:|.|.|..........||:
  Fly   534 DSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEIL--KSLGAAAPHQYFPQELPTDL----- 591

  Fly   408 HSRSSSSLNNNN---NNSHKANNNLKDLEELEVSTEDQDTENKQRRLKTTINNNIIESEQQEDMD 469
             .:.|..|:.:.   .|......:.::..|.|:: |..:.|.:...|:..|....:|.::|...:
  Fly   592 -RKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMA-ECSEPEPEPLPLEVRIKEERVEEQEQVKQE 654

  Fly   470 DEEADDADVAMLTSTPDVATLLAGASASGAASRSPTPSPSA---SPALLLSCPACGASDFETLPA 531
            |...:.                           ..|||||:   ||.
  Fly   655 DHRIEP---------------------------RRTPSPSSEHRSPH------------------ 674

  Fly   532 LCVHLDAMHSDIPAKCRDCEVIFATHRQ----LQSHCCRLPNALAGGLPPLLGASSSPLHNEEPE 592
               |....|...|...:..:.....|.|    .|||...||.  .|.|||
  Fly   675 ---HHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPT--PGQLPP--------------- 719

  Fly   593 DEEHGDDEDLEQKERLASQSEDFFHQLY-LKHKTANGCGAISHPP-------------------- 636
                               .||||.:.: |...||.......|.|
  Fly   720 -------------------REDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHH 765

  Fly   637 ----------SPIKHEPADTKDLADIQSILNMTSSSSSFLRNFEQSVNTPNSSQYSLDGRDQEEE 691
                      :|||||.|         ::|....|:.:...||.:..||
  Fly   766 PHHMARSPFFNPIKHEMA---------ALLPRPHSNDNSWENFIEVSNT---------------- 805

  Fly   692 AQDAFTSEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRVHLGAVGPAGPFRCNMCPYAVCDKAAL 756
                                  |..:  .|:.|..:.::       :.|.:|.:|...:..|:||
  Fly   806 ----------------------CETM--KLKELMKNKKI-------SDPNQCVVCDRVLSCKSAL 839

  Fly   757 VRHMRTHNGDRPYECAVCNYAFTTKANCERH---------LRNRHG-KTSREEVKRAIVYHPAED 811
            ..|.|||.|:||::|.:|..|||||.|.:.|         :||.|. ....::...|:|..
  Fly   840 QMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQ---- 900

  Fly   812 AGCEDSKSRLGE--DLADTSFRSISPTPPPPP------VNESKSQLKHMLL---------GENH- 858
               :..:...||  ||.....::.....|||.      :|...:...|...         |.||
  Fly   901 ---QHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHG 962

  Fly   859 -----LAPVNQQPPLKIQVKSLD--QLVDKKPSAPAPQQQQQQQQQEKSGSALDFSMDVLD--LS 914
                 |...:.|..:.   .::|  :..|...|:........:|:.::|.|..||...:.:  |.
  Fly   963 AHNGALGSESSQGDMD---DNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLR 1024

  Fly   915 KKPTGGASLTPAVTRTPTP-------AAVAPVTPGGVGTPDLAAAIEQQQLLLAQQQLFGAGGEY 972
            ...||..:..|...|:...       :..||.:|.                       ..|..:.
  Fly  1025 IDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPS-----------------------VHASSQV 1066

  Fly   973 MQQLFRSLMFQSQTSGFPFFPFMAP--------PPPQANPEKPPMV--SPPNR--------INPM 1019
            :::.......::........|..||        |.|:..|..||.:  ||...        .:|:
  Fly  1067 IKRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPL 1131

  Fly  1020 PVGVGVGVPVPPGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQ 1084
            |..||:.. :|||                                         ::.|::|||
  Fly  1132 PPTVGIDC-LPPG-----------------------------------------LQHHLQQQH-- 1152

  Fly  1085 FYAQRQRSGHHVMRGRGASNVAAAAAAAAAAAAATVMAGGPGSSGFGSNHHHGHGHGSHGSHGHA 1149
                     .|:|:.:         ||.||||||             .:|||
  Fly  1153 ---------QHLMQQQ---------AAVAAAAAA-------------QHHHH------------- 1173

  Fly  1150 PISEQVKCAILAQQLKAHKNTDLLQQALAHGSSSVAGNPLLHFGYPLTNPSPMHNGSSQGNGQAT 1214
                        ||:.|                       ||
  Fly  1174 ------------QQMAA-----------------------LH----------------------- 1180

  Fly  1215 AMDDDEPKLIIDEDENEHDHEVEAEDVDDFEEDEDEEEMDEPEDEPELILDEQPAEKEAEEEQEL 1279
                            :|..::                                 .:||.|.|:
  Fly  1181 ----------------QHQEQL---------------------------------RREAAEAQQ- 1195

  Fly  1280 PKPLEQLGTKEAAQKMAETILEQAIKAGKPLSPPPTKENASPANPTVATTMQEPAITAPSTNPSS 1344
                     |.||...|..    |..|.:..:||..::......|.          ..|..||
  Fly  1196 ---------KAAAAAAAAA----AAAAAQRQTPPQARDQRQEGGPG----------AGPPPNP-- 1235

  Fly  1345 LKTMIAQAEYVGKSLKEVASSPFKDESQDLVPVAKLVDNATSQNMGFNSYFRPSDVANHMEQSDE 1409
                     .:|      |..||     .:.|...|...||:|||           .|.|.|
  Fly  1236 ---------LMG------ARPPF-----GMFPNLPLFPPATTQNM-----------CNAMNQ--- 1266

  Fly  1410 EGLVASGSASESNNSGTEDVTSSSSSSEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHT 1474
                               :..|...:.|....|.|......:|..|.:.||..|:|..|..:||
  Fly  1267 -------------------IAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHT 1312

  Fly  1475 GQKPFKCSHCPLLFTTKSNCDRHLL 1499
            .::|||||.|...||||.|..:|:|
  Fly  1313 KERPFKCSICDRGFTTKGNLKQHML 1337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
peb	NP_001014722.1	C2H2 Zn finger	252..272	CDD:275368	2/19 (11%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	711..731	CDD:275368	3/19 (16%)
		C2H2 Zn finger	743..763	CDD:275368	7/19 (37%)
		zf-H2C2_2	755..780	CDD:290200	13/24 (54%)
		C2H2 Zn finger	771..789	CDD:275368	9/26 (35%)
		C2H2 Zn finger	1061..1079	CDD:275368	1/17 (6%)
		PopZ	1299..>1430	CDD:226348	22/130 (17%)
		C2H2 Zn finger	1453..1473	CDD:275370	7/19 (37%)
		zf-H2C2_2	1465..1490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1481..1502	CDD:275370	10/19 (53%)
		C2H2 Zn finger	1706..1726	CDD:275368
		zf-H2C2_2	1718..1742	CDD:290200
		C2H2 Zn finger	1734..1754	CDD:275368
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	10/35 (29%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	12/24 (50%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
		C2H2 Zn finger	826..846	CDD:275368	7/19 (37%)
		zf-H2C2_2	838..863	CDD:290200	13/24 (54%)
		zf-C2H2_2	854..922	CDD:289522	18/74 (24%)
		C2H2 Zn finger	854..874	CDD:275368	9/19 (47%)
		C2H2 Zn finger	886..906	CDD:275368	2/26 (8%)
		C2H2 Zn finger	1291..1311	CDD:275368	7/19 (37%)
		zf-H2C2_2	1303..1328	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1319..1339	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930