DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15912 and Reg-2

DIOPT Version :9

Sequence 1:	NP_572168.1	Gene:	CG15912 / 31385	FlyBaseID:	FBgn0029712	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_612043.1	Gene:	Reg-2 / 38075	FlyBaseID:	FBgn0016715	Length:	260	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	88/259 - (33%)
Similarity:	132/259 - (50%)	Gaps:	23/259 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NLKRFRLVTFDVTDTLLRLE-DPLRQYHQTAEEFGVTGVDRRRLEQCFRQQFKAMSSEHPNFGR- 72
            :|.||||:|||||:|||:.. .|.:||.:....||.. .|...|.:.|:..:..|:.::|||||
  Fly     3 SLSRFRLITFDVTNTLLQFRTTPGKQYGEIGALFGAR-CDNNELAKNFKANWYKMNRDYPNFGRD 66

  Fly    73 YSPGLDWQRWWLQLVARTFSCVDHGLAPEKLEKIGQRLISVFRTSACWSHVNGAQELVQNVR--- 134
            .:|.::||:||.:|:|.||:.....:..|||......||.:::||.||...||:.||:|.:|
  Fly    67 TNPQMEWQQWWRKLIAGTFAESGAAIPDEKLHNFSNHLIELYKTSICWQPCNGSVELLQQLRKEL 131

  Fly   135 NAGKC-VGIISNFDSSLPQVLDAMGFAGKFDFILTSYEAGVMKPERGIFEIPLQR---LQIPAEQ 195
            ...|| :|:|:|||..||.:|.........||.:.|||....||:..||:..:::   ..:..|:
  Fly   132 KPEKCKLGVIANFDPRLPTLLQNTKLDQYLDFAINSYEVQAEKPDPQIFQKAMEKSGLKNLKPEE 196

  Fly   196 ALHIGNKLDMDYEGARNCGWSGLLV-------------SNADNPHSFASLSSLLEALKTQPIRW 246
            .||||:....||..|:..||...||             .:.|..|.|.||....:.:....:.|
  Fly   197 CLHIGDGPTTDYLAAKELGWHSALVHEKSYAYLVKKYGEDIDRDHVFPSLYDFHKKISDGAVVW 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15912	NP_572168.1	DREG-2	15..219	CDD:274056	77/212 (36%)
CG15912	NP_572168.1	HAD-SF-IA-v1	16..214	CDD:273686	74/206 (36%)
Reg-2	NP_612043.1	DREG-2	8..220	CDD:274056	77/212 (36%)
Reg-2	NP_612043.1	HAD_like	76..215	CDD:304363	48/138 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450111
Domainoid	1	1.000	55	1.000	Domainoid score	I7420
eggNOG	1	0.900	-	-		E1_COG1011
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I2248
Isobase	1	0.950	-	0	Normalized mean entropy	S2956
OMA	1	1.010	-	-		QHG55252
OrthoDB	1	1.010	-	-		D100405at50557
OrthoFinder	1	1.000	-	-		FOG0002375
OrthoInspector	1	1.000	-	-		otm26628
orthoMCL	1	0.900	-	-		OOG6_102573
Panther	1	1.100	-	-	P	PTHR46191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1833
SonicParanoid	1	1.000	-	-		X2471
	14	13.790