DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usf and TFEB

DIOPT Version :9

Sequence 1:	NP_572167.3	Gene:	Usf / 31384	FlyBaseID:	FBgn0029711	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_001161299.2	Gene:	TFEB / 7942	HGNCID:	11753	Length:	490	Species:	Homo sapiens

Alignment Length:	379	Identity:	69/379 - (18%)
Similarity:	112/379 - (29%)	Gaps:	161/379 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EFGSSTSNTNTSTSPSSVNISNANPTAGPGLMTITNHHTADLSEALVHSSFANGQQSLILTSDTG 76
            :|.:..|....|..|.        |.|.||:.  ..|                     :|:|..|
Human   117 KFAAHISPAQGSPKPP--------PAASPGVR--AGH---------------------VLSSSAG 150

  Fly    77 NPLMNSQGAQIFLTICGDENSDDSQEYYTIKQEPGCDLDIHSLLPSNLQLPNNLQLPTG-CEIYL 140
            |...||..|.:.:....:...||     .|......| |:...:...:|:||.|.|.:. ..:|
Human   151 NSAPNSPMAMLHIGSNPERELDD-----VIDNIMRLD-DVLGYINPEMQMPNTLPLSSSHLNVY- 208

  Fly   141 VKETGSLMGEPPTKAAIKLELDTLSEKPLLPSVTTSSSTQSAVITAQTVNPPIPGNINTTTSTTS 205
                   ..:|...|:             |..||:||               .|.::......|.
Human   209 -------SSDPQVTAS-------------LVGVTSSS---------------CPADLTQKRELTD 238

  Fly   206 TTTTTSVLYGSHGNGHGHGHAHAQARSQPESAGQTPSSKLEAYKKRDDKRRATHNEVERRRRDKI 270
                                  |::|:..:..           :|:|:     ||.:|||||..|
Human   239 ----------------------AESRALAKER-----------QKKDN-----HNLIERRRRFNI 265

  Fly   271 NSWIFKLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSSSGRAPPND-----SKSQ 330
            |..|.:|..::|.                                        .||     :|..
Human   266 NDRIKELGMLIPK----------------------------------------ANDLDVRWNKGT 290

  Fly   331 ILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQALREELDRLKRQQQLQERFH 384
            ||..:.:||:.||.::...|:....:..|..:|:.|...:..|    ::|.|.|
Human   291 ILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQEL----EMQARVH 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usf	NP_572167.3	HLH	255..343	CDD:278439	19/92 (21%)
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..175	CDD:292573	18/93 (19%)
		HLH	247..307	CDD:238036	23/115 (20%)
		DUF3371	335..471	CDD:288684	3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840