DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usf and MITF

DIOPT Version :10

Sequence 1:NP_572167.3 Gene:Usf / 31384 FlyBaseID:FBgn0029711 Length:437 Species:Drosophila melanogaster
Sequence 2:NP_001341533.1 Gene:MITF / 4286 HGNCID:7105 Length:526 Species:Homo sapiens


Alignment Length:389 Identity:76/389 - (19%)
Similarity:131/389 - (33%) Gaps:105/389 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 TSTSPSSVNISNANPTAGPGLMTITNHHTADLSEALVHSSFANGQQSLILTSDTGNPLMNSQGAQ 86
            :.|...:|::....|:|....|.:....|...:....|...|..||.....|.|   |.|....|
Human    93 SQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTT---LANKHANQ 154

  Fly    87 IFLTICGDENSDDSQEYYTIKQEPGCDLDIHSLLPSNLQLPNN----LQLPTGCE---IYLVKET 144
            :....|.::..|     :.:...||.            ..||:    |.|.:.||   .|..:|.
Human   155 VLSLPCPNQPGD-----HVMPPVPGS------------SAPNSPMAMLTLNSNCEKEGFYKFEEQ 202

  Fly   145 GSLMGEPP-----TKAAIKLELDTLSEKPLLPSVTTSSSTQSAVI-----TAQTVNP-PIPGNIN 198
            .....|.|     ::|:. :::|.:.:    ..::..||....::     ..|..|. |:.||:.
Human   203 NRAESECPGMNTHSRASC-MQMDDVID----DIISLESSYNEEILGLMDPALQMANTLPVSGNLI 262

  Fly   199 TTTSTTSTTTTTSVLYGSHG-NGHGHGHAHAQARSQPESAGQ-------TPSSKLEAYKKRDDKR 255
            .             |||:.| ...|...:::...:.|....:       |.|......|:|  ::
Human   263 D-------------LYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKER--QK 312

  Fly   256 RATHNEVERRRRDKINSWIFKLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSSSG 320
            :..||.:|||||..||..|.:|..::|.          |..|....                   
Human   313 KDNHNLIERRRRFNINDRIKELGTLIPK----------SNDPDMRW------------------- 348

  Fly   321 RAPPNDSKSQILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQALREELDRLKRQQQLQERFH 384
                  :|..||..:.:||:.:|.|....::.......|..:|:.|...:..|    ::|.|.|
Human   349 ------NKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQEL----EMQARAH 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UsfNP_572167.3 bHLH_SF 258..347 CDD:469605 21/88 (24%)
MITFNP_001341533.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
MITF_TFEB_C_3_N 56..194 CDD:464952 25/120 (21%)
Transactivation 224..295 14/87 (16%)
bHLHzip_MITF 300..403 CDD:381496 31/144 (22%)
Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970 374..395 3/20 (15%)
DUF3371 397..516 CDD:463372 3/6 (50%)
DNA-binding regulation 401..431 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..526
Blue background indicates that the domain is not in the aligned region.

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